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| 阿司匹林对游离脂肪酸引起的大鼠肝细胞胰岛素抵抗的保护作用 | |
| 引用本文： | 张苏河,张东铭,李鹏诺,李青菊,田晨光,王转锁,张钦宪,李凤良.阿司匹林对游离脂肪酸引起的大鼠肝细胞胰岛素抵抗的保护作用[J].中华内分泌代谢杂志,2005,21(2):172-174. |
| 作者姓名： | 张苏河 张东铭 李鹏诺 李青菊 田晨光 王转锁 张钦宪 李凤良 |
| 作者单位： | 1. 450003,郑州大学第二附属医院内分泌科 2. 海南医学院附属医院内分泌科 3. 郑州大学基础医学院组织学与胚胎学教研室 |
| 摘 要： | 探讨游离脂肪酸和阿司匹林对大鼠肝细胞胰岛素受体底物2(IRS -2)的蛋白质含量及其酪氨酸残基磷酸化水平的影响,结果提示游离脂肪酸可能通过抑制IRS- 2酪氨酸残基磷酸化和降低IRS -2蛋白质含量引起肝细胞胰岛素抵抗,阿司匹林能防治游离脂肪酸引起的肝细胞胰岛素抵抗。 |
| 关 键 词： | 阿司匹林 脂肪酸类 非酯化 大鼠 胰岛素抵抗 胰岛素受体底物-2 |
| 修稿时间： | 2003年11月5日 |
Protective effect of aspirin against free fatty acid-induced insulin resistance in cultured rat hepatic cells |
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| ZHANG Su-he,ZHANG Dong-ming,LI Peng-nuo,LI Qing-ju,TIAN Chen-guang,WANG Zhuan-suo,ZHANG Qin-xian,LI Feng-liang.Protective effect of aspirin against free fatty acid-induced insulin resistance in cultured rat hepatic cells[J].Chinese Journal of Endocrinology and Metabolism,2005,21(2):172-174. | |
| Authors: | ZHANG Su-he ZHANG Dong-ming LI Peng-nuo LI Qing-ju TIAN Chen-guang WANG Zhuan-suo ZHANG Qin-xian LI Feng-liang |
| Abstract: | The effects of free fatty acid and aspirin on the abundance and tyrosine phosphorylation of insulin receptor substrate-2 (IRS-2) were studied in cultured rat hepatic cells. The results suggested that the decrease in IRS-2 abundance and tyrosine phosphorylation might play a role in free fatty acid-induced hepatic insulin resistance. Aspirin seems to prevent free fatty acid-induced insulin resistance of hepatic cells. |
| Keywords: | Aspirin Fatty acids nonesterified Rats Insulin resistance Insulin receptor substrate-2 |
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