| 福建地区2型糖尿病患者脂联素基因启动子区多态性与颈动脉内膜中层厚度有关 |
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| 引用本文： | 蔡清颜,施亚雄,李永加,陶畊.福建地区2型糖尿病患者脂联素基因启动子区多态性与颈动脉内膜中层厚度有关[J].中华内分泌代谢杂志,2009,25(2). |
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| 作者姓名： | 蔡清颜 施亚雄 李永加 陶畊 |
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| 作者单位： | 1. 福建省立医院内分泌科
2. 福建医科大学附属第二医院内分泌科,泉州,362000 |
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| 摘 要： | 目的 探讨脂联素基因启动子区-11377位点单核苷酸多态性与2型糖尿病患者颈动脉内膜中层厚度(CIMT)之间的关系.方法 采用PCR-限制性片段长度多态性(RFLP)技术在504例2型糖尿病患者(CIMT正常组254例,CIMT增厚组250例)中检测脂联素基因-11377位点多态性,同时检测血脂、空腹血糖、空腹胰岛素及血清脂联素水平.结果 脂联素基因-11377C→G基因型和等位基因频率在CIMT正常组与CIMT增厚组的分布有显著性差别(P
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| 关 键 词： | 脂联素 多态性 限制性片段长度 糖尿病 2型 颈动脉 血管内膜中层厚度 |
Association of gene polymorphism in promoter region of adiponectin gene and carotid artery intima-media thickness in patients with type 2 diabetes mellitus of Fujian |
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| CAI Qing-yan,SHI Ya-xiong,LI Yong-jia,TAO Geng.Association of gene polymorphism in promoter region of adiponectin gene and carotid artery intima-media thickness in patients with type 2 diabetes mellitus of Fujian[J].Chinese Journal of Endocrinology and Metabolism,2009,25(2). |
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| Authors: | CAI Qing-yan SHI Ya-xiong LI Yong-jia TAO Geng |
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| Abstract: | Objective To explore the association of-11377 site single nucleotide polymorphism in promoter region of adiponectin gene and carotid intima-media thickness(CIMT)in patients with type 2 diabetes mellitus.Methods The adiponectin gene-11377C→G polymorphism was identified by PCR-restriction fragment length polymorphism(RFLP)in 504 patients with type 2 diabetes mellitus(250 patients with increased CIMT and254 Datients with normal CIMT). Serum lipid and fasting plasma glucose were detected by full automatic biochemical analysor.fasting serum insulin(FINS) was measured by radioimmunoassay,and serum adiponectin level was assessed by ELISA.Results The frequencies of adiponectin gene-11377C→G genotype and allele were different between type 2 diabetic patients with normal and increased CIMT(P
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| Keywords: | Adiponectin Polymorphism restriction fragment length Diabetes mellitus type 2 Carotid artery Intima-media thickness |
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