| 同型半胱氨酸及其相关酶基因多态性与糖尿病周围神经病变的关系 |
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| 引用本文： | 孙磊,陈丽,任建民,王德全,郑秀英,许玲.同型半胱氨酸及其相关酶基因多态性与糖尿病周围神经病变的关系[J].中华内分泌代谢杂志,2004,20(6):536-537. |
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| 作者姓名： | 孙磊 陈丽 任建民 王德全 郑秀英 许玲 |
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| 作者单位： | 1. 250012,济南山东大学齐鲁医院内分泌科
2. 250012,济南山东大学齐鲁医院职工保健科 |
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| 摘 要： | 研究对象为 2型糖尿病 (DM )有周围神经病变组 (60例 )、2型DM无周围神经病变组 (4 6例 )和正常对照组 (5 0例 )。分别测定 3组血浆同型半胱氨酸 (Hcy) ,血清叶酸、维生素B12 水平及Hcy代谢关键酶亚甲基四氢叶酸还原酶 (MTHFR)的基因型。结果显示 ,高Hcy及低叶酸、维生素B12 水平与 2型DM患者伴发周围神经病变相关 ,而MTHFR的基因多态性只与DM有关而与DM周围神经病变无相关性。
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| 关 键 词： | 糖尿病 2型 周围神经病变 同型半胱氨酸 亚甲基四氢叶酸还原酶 多态现象(遗传学) |
| 修稿时间： | 2003年7月30日 |
Relationship of plasma homocysteine and gene polymorphism of homocysteine metabolism related enzyme with diabetic peripheral neuropathy |
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| SUN Lei ,CHEN Li,REN Jian-min,WANG De-quan,ZHENG Xiu-ying,XU Ling.Relationship of plasma homocysteine and gene polymorphism of homocysteine metabolism related enzyme with diabetic peripheral neuropathy[J].Chinese Journal of Endocrinology and Metabolism,2004,20(6):536-537. |
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| Authors: | SUN Lei CHEN Li REN Jian-min WANG De-quan ZHENG Xiu-ying XU Ling |
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| Institution: | SUN Lei *,CHEN Li,REN Jian-min,WANG De-quan,ZHENG Xiu-ying,XU Ling. *Department of Endocrinology,Qilu Hospital,Shandong University,Jinan 250012 |
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| Abstract: | Sixty cases of type 2 diabetes with diabetic peripheral neuropathy (DPN), 46 cases of type 2 diabetes without DPN and 50 healthy persons were recruited. Plasma homocysteine (Hcy), serum folic acid, vitamin B 12 levels and the mutations of Hcy metabolism related enzyme-methyhenetetrahydrofolate reductase (MTHFR) were assayed in individuals in this study. The results showed that high Hcy, low folic acid and vitamin B 12 levels are related with DPN in the patients with type 2 diabetes. The mutation of MTHFR C677T is associated with diabetes, but not with DPN. |
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| Keywords: | Diabetes mellitus type 2 Peripheral neuropathies Homocysteine Methylenetetrahydrofolate reductase Polymorphism (Genetics) |
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