| Graves病中某些骨代谢指标的测定 |
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| 引用本文： | 程梅芬 王洪复. Graves病中某些骨代谢指标的测定[J]. 中华内分泌代谢杂志, 1990, 6(3): 160-162 |
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| 作者姓名： | 程梅芬 王洪复 |
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| 作者单位： | 上海医科大学华山医院内科内分泌组(程梅芬，杨秀芳，朱禧星)，上海放射医学研究所(王洪复) |
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| 摘 要： | 本文测定了31例Graves病病人的血清Ca、P、AKP,iPTH,血浆cAMP,尿Hyp以及骨矿含量(BMC)。结果示约有66.67％的病人BMC降低,而血清Ca、P、iPTH,血浆cAMP均在正常范围内,提示约有54.6％的病人血清AKP升高,但若无肝病AKP一般不超过25金氏单位;血清T_3与尿Hyp,尿Hyp与血清AKP间有正相关关系,而尿Hyp与BMC间呈负相关关系,所以血清AKP和尿Hyp可作为Graves病骨代谢负平衡的指标。这些骨质改变可能直接由甲状腺激素过多所引起。
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| 关 键 词： | 骨矿含量 免疫反应性甲状旁腺素 羟脯氦酸 环-磷酸腺苷 |
INVESTIGATION OF BONE METABOLISM IN GRAVES'' DISEASE |
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| Cheng Mei-fen Dept. of Internal Medicine,Hua Shan Hospital,Shanghai Medical University. INVESTIGATION OF BONE METABOLISM IN GRAVES'' DISEASE[J]. Chinese Journal of Endocrinology and Metabolism, 1990, 6(3): 160-162 |
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| Authors: | Cheng Mei-fen Dept. of Internal Medicine Hua Shan Hospital Shanghai Medical University |
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| Abstract: | Serum Ca, P, AKP, plasma iPTH, cAMP, urinary Hyp and BMC were measured in 31 cases of Graves' disease. The results showed that about 66.67% of the patients (including 21 controlled and 10 uncontrolled cases) had a decreased BMC, while serum Ca, P, plasma iPTH, cAMP were within the normal range. The data also showed that about 54.6% of the patients had increased serum AKP, but it would not exceed 25 U if no hepatic disease existed. There were positive correlations between serum T, and urinary Hyp, and between urinary Hyp and serum AKP, but a negative correlation between urinary Hyp and BMC. It was suggested that serum AKP and urinary Hyp could be considered as the indices of negative balance of bone metabolism in Graves' disease, and probably it was induced by excessive thyroid hormone directly. |
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| Keywords: | Bone mineral content Immuno-reactive parathyroid hormone Hydroxyproline Cyclic adenosine monophosphate |
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