| 糖尿病微血管病相关蛋白的研究进展 |
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| 引用本文： | 汤玮,刘志民.糖尿病微血管病相关蛋白的研究进展[J].中华内分泌代谢杂志,2007,23(2):189-192. |
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| 作者姓名： | 汤玮 刘志民 |
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| 作者单位： | 200003,上海市第二军医大学附属长征医院内分泌科 |
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| 基金项目： | 上海市科委科技攻关重大项目（04DZ19113） |
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| 摘 要： | 糖尿病微血管病是多因素协同作用导致的糖尿病常见慢性并发症，单纯纠正高血糖不能完全预防糖尿病微血管病变发生和阻止其发展进程，针对病理机制进行干预和治疗是必要的。本文对已发现与糖尿病微血管病发生和发展相关的多种蛋白进行综述，为筛选糖尿病微血管病的早期诊断和病因治疗靶向因子提供基础。
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| 关 键 词： | 糖尿病血管病变 多元醇代谢通路 高级糖基化终产物 氧化应激 |
| 修稿时间： | 2006-04-10 |
Progress in proteins related to diabetic microangiopathy |
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| TANG Wei,LIU Zhi-min.Progress in proteins related to diabetic microangiopathy[J].Chinese Journal of Endocrinology and Metabolism,2007,23(2):189-192. |
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| Authors: | TANG Wei LIU Zhi-min |
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| Institution: | Department of Endocrinology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China |
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| Abstract: | Diabetic microangiopathy is one of the most common chronic diabetic complications, which is associated with the genetic predispositions and environmental factors. Well-controlled blood glucose alone can not reduce the morbility or prevent the process of diabetic microangiopathy. The therapy aiming at the pathogenesis is an urgent request. The various proteins related to the development and progression of diabetic microangiopathiy were reviewed, aiming at providing the potential target for early diagnosis and efficient therapy. |
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| Keywords: | Diabetic angiopathies Polyol pathway Glycosylation end products advanced Oxidative stress |
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