Low serum choline and high serum betaine levels are associated with favorable components of metabolic syndrome in Newfoundland population |
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| Institution: | 1. College of Life Sciences, Qingdao University, No.308,Ningxia Road, Qingdao, Shandong, China;2. Faculty of Medicine, Memorial University, 300 Prince Philip Drive, St. John''s, NL, Canada;3. Xiangyang Central Hospital, Affiliated Hospital Of Hubei University of Arts and Science, Xiangyang, Hubei Province 441021, China;4. The Department of Endocrinology, the First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China;1. Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, United States of America;2. Research Service, Ralph H. Johnson VA Medical Center, Charleston, SC, United States of America;3. Division of Endocrinology, Department of Medicine, Medical University of South Carolina, Charleston, SC, United States of America;4. Section of Endocrinology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States of America;5. Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States of America;6. Department of Ophthalmology and Ross Eye Institute, University at Buffalo & SUNY Eye Institute, State University of New York, Buffalo, NY, United States of America;1. Washington University School of Medicine, St. Louis, MO, United States of America;2. Jaeb Center for Health Research, Tampa, FL, United States of America;3. University of Michigan, Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, Ann Arbor, MI, United States of America;4. Yale University School of Medicine, New Haven, CT, United States of America;5. Northwestern University, Chicago, IL, United States of America;6. Univeristy Hospitals of Cleveland, Cleveland, OH, United States of America;7. University of Florida, Gainesville, FL, United States of America;8. Children''s Hospital of Philadelphia, Philadelphia, PA, United States of America;9. UPMC Children''s Hospital of Pittsburgh, Pittsburgh, PA, United States of America;10. Barbara Davis Center for Diabetes, Aurora, CO, United States of America;11. University of Pennsylvania Perelman School of Medicine, Rodebaugh Diabetes Center, Philadelphia, PA, United States of America;1. Department of Ophthalmology and Visual Sciences, Case Western Reserve University, School of Medicine, Cleveland, OH, United States of America;2. Department of Pharmacology, Case Western Reserve University, School of Medicine, Cleveland, OH, United States of America;3. Louis Stokes VA Medical Center, Cleveland, OH, United States of America;4. James E. Van Zandt VA Medical Center, Altoona, PA, United States of America;1. Medical Care (physical examination) Center, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China;2. Department of Endocrinology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China;3. Department of Endocrinology, Peking University International Hospital, Beijing 102206, China;4. Diabetes Center, Department of Endocrinology, The 306th Hospital of PLA, Beijing, China;5. Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu 610041, China;6. Department of Endocrinology and Metabolism, Peking University People''s Hospital, Beijing 100044, China;1. Department of Epidemiology, Colorado School of Public Health, Univeristy of Colorado Anschutz Medical Campus, Aurora, CO 80045;2. Division of Endocrinology, Diabetes and Metabolism, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045;3. VA Eastern Colorado Health Care System, Denver, CO 80220;1. Diabetology Department, Centre Hopitalier Sud Francilien, Corbeil Essonnes, France;2. Diabetology Department, AP-HP, Hôpital Pitié-Salpêtrière, F-75013 Paris, France;3. Centre de recherche des Cordeliers INSERM U1138 Team “Diabetes, metabolic diseases and comorbidities”, 15 rue de l''Ecole de Médecine, 75270 Paris cedex 06, France;4. Vascular Surgery Department AP-HP, Hôpital Pitié-Salpêtrière, F-75013 Paris, France;5. Clinical Research Unit centre hospitalier sud Francilien, 40 Avenue Serge Dassault, 91100 Corbeil-Essonnes, France;6. Sorbonne Université, 15 rue de l''Ecole de Médecine, 75006 Paris, France |
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| Abstract: | BackgroundWe investigated the relationships between serum choline and betaine levels with metabolic syndrome-related indices in the general population of Newfoundland.Methods1081 adults were selected from the CODING study. Serum choline and betaine levels were measured. Major confounding factors were controlled in all analyses.ResultsPartial correlation and linear regression analysis showed that serum choline levels were positively associated with systolic blood pressure (r: 0.124), serum TG levels (r: 0.132) and negatively correlated with serum glucose levels (r: ?0.121) in males (p < 0.01 for all). In females, serum choline levels were positively correlated with serum TG, TC and HDL levels (r: 0.104 to 0.148, p < 0.05 for all). Serum betaine levels were negatively associated with serum TG, TC, LDL and insulin levels, and with atherogenic index and HOMA-IR index in males (r: ?0.081 to ?0.179, p < 0.05 for all). In females, serum betaine levels were negatively associated with serum TG, hsCRP and insulin levels, and with HOMA-IR index (r: ?0.092 to ?0.213, p < 0.05 for all). Moreover, subjects with serum choline levels in the highest tertile showed highest serum TG levels and systolic blood pressure in males, and highest serum lipids levels in females. Subjects with the highest serum betaine levels had the lowest serum lipids levels, atherogenic index, IR severity in males, and the lowest serum TG and hsCRP levels, and IR severity in females.ConclusionLow serum choline and high serum betaine levels are associated with favorable components of metabolic syndrome in general adults. |
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