| KIF6基因rs20455多态性与中国北方汉族人冠心病及血脂水平的关联研究 |
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| 引用本文： | 许文燊,鄢盛恺,杨辉,夏良裕.KIF6基因rs20455多态性与中国北方汉族人冠心病及血脂水平的关联研究[J].中国分子心脏病学杂志,2011,11(6):350-354. |
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| 作者姓名： | 许文燊 鄢盛恺 杨辉 夏良裕 |
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| 作者单位： | 1. 卫生部中日友好医院检验科 10029
2. 中国医学科学院北京协和医学院检验科 100730 |
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| 摘 要： | 目的分析KIF6基因rs20455多态性与中国北方汉族人群冠心病及血脂水平的关系。方法收集164例冠心病(CHD)患者及152例健康人的外周血标本;应用聚合酶链反应-限制性片段长度多态性技术检测KIF6 rs20455多态性;研究基因多态性对血糖、血脂水平的可能影响。结果中国北方汉族人KIF6基因rs20455多态性位点TT、TC、CC基因型频率分别为0.291,0.491与0.218;T等位基因,C等位基因频率分别为0.536与0.464。基因型和等位基因频率在组间分布差异均无统计学意义(P>0.05)。本研究对象rs20455多态性基因型和等位基因频率分布与高加索,非裔美洲人群有统计学差异(P<0.001)。rs20455基因多态性与血糖、血脂水平、性别、年龄、高血压病史无显著性关联。Logistic回归显示,年龄、TG、HbAlc是本组研究对象发生冠心病的主要危险因素(OR分别为1.178、26.18、17.415,P<0.05)。C等位基因不是发生冠心病的独立危险因素。结论未发现KIF6基因rs20455多态性与本研究人群的冠心病发生及血脂水平存在明显关联性。
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| 关 键 词： | 冠心病 驱动蛋白分子6 多态性 |
Association of KIF6 gene rs20455 polymorphisms with coronary heart disease and the levels of serum lipids in Han nationality from northern China |
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| Xu Wen-shen
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YAN Sheng-kai
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YANG Hui
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XIA Liang-yu.Association of KIF6 gene rs20455 polymorphisms with coronary heart disease and the levels of serum lipids in Han nationality from northern China[J].Molecular Cardiology of China,2011,11(6):350-354. |
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| Authors: | Xu Wen-shen YAN Sheng-kai YANG Hui XIA Liang-yu |
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| Institution: | Xu Wen-shen1,YAN Sheng-kai1,YANG Hui1,XIA Liang-yu2. 1 Department of Laboratory Medicine,China-Japan Friendship Hospital,Beijing 100029,China,2 Department of Laboratory Medicine,Peking Union Medical College Hospital,PUMC & CAMS,Beijing 100730,China. |
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| Abstract: | Objective To investigate the association of rs20455 polymorphisms in KIF6 gene with coronary heart disease(CHD) and levels of serum lipids in Han nationality from northern China.Methods The KIF6 rs20455 genotypes in 152 controls and 164 CHD patients were analyzed with polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP). The effects of gene variation on hemoglobinA1c (HbA1c),serum lipids and glucose(Glu) were also studied.Results The genotype frequencies of TT,TC,CC were 0.291,0.491 ... |
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| Keywords: | Coronary heart disease KIF6 Polymorphisms |
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