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| 白介素-6基因启动子区域-634C/G多态性与颈动脉粥样硬化的关系 | |
| 引用本文： | 谢高强,王浩,史平,任福秀,梁立荣,赵连成,李莹,武阳丰.白介素-6基因启动子区域-634C/G多态性与颈动脉粥样硬化的关系[J].中国分子心脏病学杂志,2010,11(3):171-175. |
| 作者姓名： | 谢高强 王浩 史平 任福秀 梁立荣 赵连成 李莹 武阳丰 |
| 作者单位： | 1. 100037,北京,中国医学科学院阜外心血管病医院,卫生部心血管病防治研究中心;北京大学临床研究所 2. 中国医学科学院阜外心血管病医院,卫生部心血管病防治研究中心,北京,100037 3. 北京市石景山区疾病预防控制中心 4. 首都医科大学附属北京朝阳医院 5. 北京大学临床研究所;中国乔治中心 |
| 基金项目： | 国家自然基金，国家"十五"攻关项目，阜外心血管病医院院所青年科学基金 |
| 摘 要： | 目的研究白介素-6基因-634C/G多态性与颈动脉斑块的关系及其与其它危险因素间的交互作用。方法 2005年秋-2006年春,在北京社区整群随机抽样人群中进行流行病学调查,询问病史及生活方式相关危险因素,检测颈动脉内中膜厚度（IMT）、颈动脉斑块、白介素-6基因启动子区域-634C/G位点基因型及相关生化指标。结果共1422例资料完整者进行分析,-634C/C、-634C/G和-634G/G基因型频率分别为46.8%（666）、42.7%（607）和10.5%（149）,符合Hardy-Weinberg平衡（p=0.540）。调整年龄和性别后,与-634C/C基因型相比,-634C/G基因型出现颈动脉斑块的危险比值比（OR）为1.12（95%可信限：0.88-1.43,p=0.354）,-634G/G基因型为1.49（95%可信限：1.02-2.18,p=0.041）。进一步调整其它危险因素后,结果依然如此。交互作用分析发现,-634C/C＋C/G携带者高血压、高胆固醇血症、吸烟与颈动脉斑块的关联强度低于-634G/G携带者,多因素交互作用模型发现,-634C/G、高血压、高胆固醇血症对颈动脉斑块存在显著交互作用（p=0.004）。结论白介素-6基因-634G/G基因型携带者颈动脉粥样硬化危险显著增加,而且这种作用与高血压和高胆固醇血症之间存在交互作用。 |
| 关 键 词： | -634C/G 白介素 -6 颈动脉斑块 交互作用 |
Relationship Between Interleukin(IL)-6 Gene-634C/G Polymorphisms and Carotid Atherosclerosis |
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| XIE Gao-qiang,WANG Hao,SHI Ping,REN Fu-xiu,LIANG Li-rong,ZHAO Lian-cheng,LI Ying,WU Yang-feng.Relationship Between Interleukin(IL)-6 Gene-634C/G Polymorphisms and Carotid Atherosclerosis[J].Molecular Cardiology of China,2010,11(3):171-175. | |
| Authors: | XIE Gao-qiang WANG Hao SHI Ping REN Fu-xiu LIANG Li-rong ZHAO Lian-cheng LI Ying WU Yang-feng |
| Institution: | 4,56. 1 Fuwai Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100037, China; 2 Shijingshan Center of Diseases Control, Beijing, China; 3 Beijing Chao-yang Hospital, Capital Medical University, Beijing, China;4Peking University Clinical Research Institute , Beijing, China;5 The George Institute, Beijing, China. |
| Abstract: | Objective To explore the association between interleukin-6 （IL-6） -634C/G polymorphisms and early carotid atherosclerosis and the modifi ed effect of risk factors on the association. Methods A community-based survey was carried out in 1,422 participants in rural of Beijing in 2005-2006. Carotid plague was defi ned as carotid Intima Media Thickness （IMT） =1.3mm or a focal raised lesion ≥0.5mm tested by B mode ultrasound. Results The frequencies of -634C/C,C/G, and G/G genotype were 46.8%（666）, 42.7%（607）, and 10.5%（149） in the study population. After adjusted for age and sex, odds ratio for carotid plaque were 1.12 （95%CI： 0.88-1.43, p=0.354） for -634C/G, and 1.49 （95%CI： 1.02-2.18, p=0.041） for -634G/G as compared with -634C/C in the whole sample. Adjustment for other risk factors did not change this result. More important, the risks of hypertension, hypercholesterolemia, and smoking for carotid plaque were greater in those with -634G/G than those with C/C＋C/G. There were signifi cant Interaction of -634C/G polymorphism with hypertension and high cholesterol for developing carotid plaque （p=0.004）. Conclusion The interleukin-6 gene polymorphisms of -634C/G is not only signifi cantly associated with carotid plaque, but also signifi cantly modifi ed the risk of hypertension and hypercholesterolaemia on carotid plaque. |
| Keywords: | -634C/G |
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