| SGLT2抑制剂治疗心力衰竭潜在机制的新认识 |
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| 引用本文： | 廖梦阳,廖玉华,余淼,陈霄,袁璟,程翔.SGLT2抑制剂治疗心力衰竭潜在机制的新认识[J].临床心血管病杂志,2022(1):1-6. |
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| 作者姓名： | 廖梦阳 廖玉华 余淼 陈霄 袁璟 程翔 |
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| 作者单位： | 华中科技大学同济医学院附属协和医院心内科 |
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| 摘 要： | 钠-葡萄糖协同转运蛋白2 (SGLT2)抑制剂已成为治疗心力衰竭(心衰)的新兴药物,但其作用机制尚不清楚.健康人心肌细胞仅表达SGLT1,SGLT2定位在肾脏近曲小管和心外膜脂肪组织(EAT),在疾病状态下高表达.舒张性心衰患者发生EAT堆积,EAT高表达SGLT2和分泌脂肪细胞因子,介导心肌纤维化和心肌肥厚;心肌细胞...
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| 关 键 词： | 心力衰竭 钠-葡萄糖协同转运蛋白2抑制剂 心外膜脂肪组织 钠-葡萄糖协同转运蛋白2/1 心脏代谢重构 |
Novel insight into the potential mechanisms of SGLT2 inhibitors in heart failure |
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| LIAO Mengyang,LIAO Yuhua,YU Miao,CHEN Xiao,YUAN Jing,CHENG Xiang.Novel insight into the potential mechanisms of SGLT2 inhibitors in heart failure[J].Journal of Clinical Cardiology,2022(1):1-6. |
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| Authors: | LIAO Mengyang LIAO Yuhua YU Miao CHEN Xiao YUAN Jing CHENG Xiang |
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| Institution: | (Department of Cardiology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan.430022,China) |
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| Abstract: | The efficacy of sodium glucose cotransporter 2(SGLT2) inhibitors in the treatment of heart failure have been demonstrated in cardiovascular outcome trials, but its mechanism is not clear. Cardiomyocytes in healthy human only express SGLT1, and SGLT2 is localized in renal proximal convoluted tubules and epicardial adipose tissue(EAT), which is highly expressed in disease state. EAT accumulation occurs in patients with diastolic heart failure. EAT highly expresses SGLT2 and secretes adipocytokines, which mediates myocardial fibrosis and myocardial hypertrophy;High expression of SGLT1 in cardiomyocytes mediates intracellular Na;overload. Based on the distribution of SGLT2/1 in heart and kidney, we speculate that the potential mechanism of SGLT2 inhibitor in the treatment of heart failure mainly involves cardiac hemodynamics and cardiac metabolic remodeling. EAT-SGLT2 may be an important target for the prevention and treatment of cardiac metabolic remodeling. |
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| Keywords: | heart failure sodium glucose cotransporter 2 inhibitor epicardial adipose tissue sodium glucose cotransporter 2/1 cardiac metabolic remodeling |
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