首页 | 本学科首页   官方微博 | 高级检索  
检索        

冠心病患者阿司匹林抵抗相关因素分析
引用本文:尹承华,王建春,赵勇,李春梅,李元堂,邵建华.冠心病患者阿司匹林抵抗相关因素分析[J].临床心血管病杂志,2009,25(9).
作者姓名:尹承华  王建春  赵勇  李春梅  李元堂  邵建华
作者单位:1. 济南市第二人民医院内二科,济南,250001
2. 山东大学附属省立医院老年心血管病科
3. 山东大学附属省立医院检验科
摘    要:目的:探讨冠心病患者阿司匹林抵抗(AR)的发生率,并对其临床相关因素进行分析。方法:选择264例正规服用阿司匹林(75~100mg/d)超过1个月的冠心病患者,分别用胶原(COL)和二磷酸腺苷(ADP)作为诱导剂测定其静脉血中血小板聚集功能,根据结果分为AR组、阿司匹林半抵抗(ASR)组和阿司匹林敏感(AS)组,分析各组间的临床特征,找出可能与AR有关的因素。结果:所有入选者中AR发生率为8.71%(23/264),ASR发生率为18.56%(49/264),AR+ASR总发生率27.27%。AR组、ASR组中,女性和伴糖尿病者及外周血小板计数较AS组高(P<0.05)。结论:冠心病患者AR+ASR的总发生率为27.27%,其发生可能与性别、伴糖尿病以及外周血小板数目有关。

关 键 词:冠状动脉疾病  阿司匹林抵抗  相关因素  

Correlative factors analysis of aspirin resistance in patients with coronary heart disease
YIN Chenghua WANG Jianchun ZHAO YongLI Chunmei LI Yuantang SHAO Jianhua.Correlative factors analysis of aspirin resistance in patients with coronary heart disease[J].Journal of Clinical Cardiology,2009,25(9).
Authors:YIN Chenghua WANG Jianchun ZHAO YongLI Chunmei LI Yuantang SHAO Jianhua
Institution:1Department of Cardiology;the Second Hospital of Jinan City;Jinan;250001;China;2Department of Cardiology in Gerontology;3Department of Clinical Laboratory;Shandong Provincial Hospital Affiliated to Shandong University
Abstract:Objective:To investigate the incidence and correlative factors of aspirin resistance (AR) in the patients with coronary heart disease. Method:We enrolled 264 patients with coronary heart disease who had taken aspirin regularly (75-100 mg/d) for more than one month.Platelet aggregation function induced by adenosine diphosphate(ADP)and collagen(COL)were determined by whole blood impedance method.According to the results,all patients were divided into three groups: aspirin resistance(AR) group,aspirin semiresp...
Keywords:coronary disease  aspirin resistance  correlative factors  
本文献已被 CNKI 万方数据 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号