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曲美他嗪对冠状动脉介入术过程中血清白细胞介素6和C反应蛋白的影响
引用本文:刘素云,李拥军,张辉,杨蓉,祖秀光,郝玉明.曲美他嗪对冠状动脉介入术过程中血清白细胞介素6和C反应蛋白的影响[J].临床心血管病杂志,2007,23(1):15-17.
作者姓名:刘素云  李拥军  张辉  杨蓉  祖秀光  郝玉明
作者单位:河北医科大学第二医院心内科,石家庄,050000
摘    要:目的观察曲美他嗪对不稳定型心绞痛患者冠状动脉介入术(PCI)过程中血清白细胞介素6(IL-6) 和C 反应蛋白(CRP) 浓度的影响.方法75 例拟行PCI治疗的不稳定型心绞痛患者,随机分为曲美他嗪组和对照组,分别于PCI前、术后即刻(0h)、2 h 和6 h 采取冠状静脉窦血样测定血清IL-6 的浓度;另于术前、术后6、24和48 h 采取肘静脉血样,测定血清CRP 的浓度.血清IL-6 和CRP 的浓度均以ELISA双抗体夹心法进行测定.结果2组患者临床特征及靶病变情况差异无统计学意义.对照组IL-6 浓度在术后即刻开始高于曲美他嗪组,术后2 h和6 h差异进一步增大(P<0.05~0.01) .对照组的CRP 浓度在术后6、24 和48 h 都明显高于曲美他嗪组(P<0.05~0.01).结论曲美他嗪能抑制不稳定型心绞痛患者PCI过程中血清IL-6 和CRP浓度的升高.

关 键 词:C反应蛋白  白细胞介素6  冠状动脉介入治疗  曲美他嗪
文章编号:1001-1439(2007)01-0015-03
修稿时间:2006年4月14日

Effects of trimetazidine on serum levels of IL-6 and CRP of UAP patients undergoing precutaneous coronary intervention
LIU Suyun,LI Yongjun,ZHANG Hui,YANG Rong,ZU Xiuguang,HAO Yuming.Effects of trimetazidine on serum levels of IL-6 and CRP of UAP patients undergoing precutaneous coronary intervention[J].Journal of Clinical Cardiology,2007,23(1):15-17.
Authors:LIU Suyun  LI Yongjun  ZHANG Hui  YANG Rong  ZU Xiuguang  HAO Yuming
Abstract:Objective:To explore the effects of trimetazidine on serum interleukin-6(IL-6) and C-reactive protein(CRP) levels of unstable angina pectoris (UAP) patient undergoing precutaneous coronary intervenetion(PCI). Method:A total of 75 UAP patients were randomly divided into trimetazidine group and control group. Coronary sinus blood was collected before angioplasty, 2 h and 6 h after angioplasty to measure the content of IL-6. Veins blood was collected before angioplasty, 6 h, 24 h and 48 h after angioplasty to measure the serum content of CRP. The serum levels of IL-6 and CRP were measured by ELISA. Result:There was no significant difference of the target lesions or the clinic characteristics between the two groups. The serum level of IL-6 was significantly higher in control group than that in trimetazidine group immediate after angioplasty , also keep raising at 2 h and 6 h (P<0.01). The serum level of CRP was significantly higher in control group than that in trimetazidine group at 6 h as well as 24 h and 48 h(P<0. 01) .Conclusion:The results suggest that trimetazidine significantly reduce the production of IL-6 and CRP during PCI, which may account for the lower rate of cardiovascular events after trimetazidine treatment.
Keywords:C-reaction protein  Interleukin-6  Percutaneous coronary intervention  Trimetazidine
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