Associations of serum cystatin C and its change with new-onset cardiovascular disease in Chinese general population |
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| Institution: | 1. Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou 510515, China;2. Department of Nephrology, Shenzhen Second People''s Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen 518035, China;3. Institute of Biomedicine, Anhui Medical University, Hefei 230032, China;1. Department of Cardiology, Rigshospitalet, University Hospital, Copenhagen, Denmark;2. Department of Cardiology, Zealand University Hospital, Roskilde, Denmark;3. Novartis Healthcare, Denmark;4. I2minds, Aarhus, Denmark;5. Danish Institute for Health Services Research, Copenhagen, Denmark;1. Association for Cardiac Research, Rome, Italy;2. EA 4650, Signalisation, électrophysiologie et imagerie des lésions d''ischémie reperfusion myocardique, UNICAEN, 14000 Caen, France;3. Research Centre for Food and Nutrition, Council for Agricultural Research and Economics (CREA-AN), Rome, Italy;1. Division of Cardiology, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul, Republic of Korea;2. Division of Hematology & Medical Oncology, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul, Republic of Korea;1. Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, Japan;2. Graduate School of Public Health, Shizuoka Graduate University of Public Health, Aoi-ku, Shizuoka, Japan;3. Department of Geriatric Medicine and Neurology, Ehime University Graduate School of Medicine, Toon City, Japan;4. Department of Anti-aging Medicine, Ehime University Graduate School of Medicine, Toon City, Japan |
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| Abstract: | Background and aimsThe relation of serum cystatin C with new-onset cardiovascular disease (CVD) remains uncertain. We aimed to evaluate the prospective associations of serum cystatin C and its change with new-onset CVD in Chinese general population.Methods and resultsA total of 7064 participants free of CVD at baseline were enrolled from the China Health and Retirement Longitudinal Study. The change in serum cystatin C was calculated as cystatin C concentration at 2015 wave minus that at baseline (2011 wave). The primary outcome was new-onset CVD, defined as self-reported physician-diagnosed heart disease, stroke, or both during follow-up. The secondary outcomes were new-onset heart disease, and new-onset stroke. During a median follow-up duration of 7.0 years, a total of 1116 (15.8%) subjects developed new-onset CVD. Overall, after the adjustments for eGFR and other important covariates, there was a positive association between serum cystatin C and new-onset CVD (per SD mg/L increment; adjusted HR, 1.13; 95%CI: 1.08,1.18). When cystatin C was assessed as quintiles, the adjusted HRs for participants in the second, third, fourth and fifth quintiles were 1.15 (95%CI: 0.93, 1.41), 1.37 (95%CI: 1.11, 1.68), 1.47 (95%CI: 1.19, 1.81), and 2.03 (95%CI: 1.60, 2.56), respectively, compared with those in quintile 1 (P for trend<0.001). Furthermore, there was a positive association between the increase in cystatin C concentration and the subsequent new-onset CVD (per SD mg/L increment; adjusted HR, 1.14; 95%CI: 1.02,1.27).ConclusionBoth serum cystatin C and its increase were positively associated with new-onset CVD among Chinese general population. |
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| Keywords: | Cystatin C Cardiovascular disease Heart disease Stroke CHARLS |
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