Is handgrip strength a marker of muscle and physical function of the lower limbs? Sex differences in older adults with obesity期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Is handgrip strength a marker of muscle and physical function of the lower limbs? Sex differences in older adults with obesity

Institution:	1. Department of Medicine, University of Verona, Verona, Italy;2. Department of Neuroscience, Biomedicine and Movement, University of Verona, Verona, Italy;3. Department of Medicine, Section of Geriatrics, Healthy Aging Center Verona, Italy;4. Section of Geriatrics, Department of Medicine, Treviso, Italy;1. Department of Endocrinology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico;2. Department of Nephrology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico;3. Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico;1. Student Research Committee, Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran;2. Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran;3. Consultant Haematologist and Senior Lecturer, Department of Haematology and Blood Transfusion, Faculty of Clinical Science, College of Medicine of the University of Lagos, Nigeria;4. Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran;5. Pediatrics Gastroenterology, Department of Pediatrics, School of Medicine Children''s Medical Center, Tehran University of Medical Sciences, Tehran, Iran;6. Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran;7. Department of Biorepository, Biomedical Research Administration, King Fahad Medical City, Riyadh, Saudi Arabia;8. College of Medicine, Alfaisal University, Riyadh, Saudi Arabia;9. College of Graduate Health Sciences, University of Tennessee Health Science Center, Memphis, TN, USA;1. Department of Nutrition and Dietetics, School of Health Sciences and Education, Harokopio University, Athens, Greece;2. School of Medicine Sydney, University of Notre Dame, Sydney, Australia;3. First Cardiology Clinic, School of Medicine, University of Athens, Athens, Greece;4. School of Psychology, University of Surrey, Guildford, UK;5. Faculty of Health, University of Canberra, Canberra, Australia;1. 2nd Department of Internal Medicine, Medical Faculty of Charles University and University Hospital, Pilsen, Czech Republic;2. Biomedical Center, Medical Faculty of Charles University, Pilsen, Czech Republic;3. Centre for Cardiovascular Prevention, First Faculty of Medicine, Charles, University and Thomayer Hospital, Prague, Czech Republic;4. Laboratory of Immunochemical Diagnostics, University Hospital, Pilsen, Czech Republic

Abstract:	Background and aimsIn this cross-sectional study we investigate the association between handgrip strength (HGS) and muscle function of the lower limbs and the predictors of the appendicular lean mass index (ALMI) in older adults with obesity of both sexes.Methods and resultsEighty-four older (67 ± 5 years) men (N = 44) and women (N = 40) with obesity (body mass index (BMI) 33 ± 4 kg/m²) performed: the HGS, isokinetic knee extensors (KE) and flexors (KF) muscle strength and power and Short Physical Performance Battery (SPPB). The correlation between HGS and lower limbs muscle function was evaluated, and four multiple hierarchical linear models were built to assess the contribution of each ALMI predictor (i.e., HGS, BMI, SPPB, muscle strength and power).In men, HGS was weakly-to-moderately associated (p < 0.05) with KE, KF muscle function and physical performance. In women, HGS showed a weak association (p < 0.05) with KE muscle function. The significant predictors of ALMI were only the BMI in women, whereas in the group of men BMI, KE maximal strength and power better explain the variance in ALMI than HGS alone.ConclusionOur results suggest that HGS should not be used alone as a marker of lower muscle nor physical function. Sex differences exist with the BMI that is a contributor of ALMI both in men and women. However, at least in the group of men, markers related to strength and power of the lower limbs can better describe variations in ALMI compared to HGS in this kind of population.Clinical trial registrationNA.

Keywords:	Obesity Sarcopenia Grip strength Muscle function Muscle mass HGS"} {"#name":"keyword" "$":{"id":"kwrd0040"} "$$":[{"#name":"text" "_":"Handgrip Strength ALMI"} {"#name":"keyword" "$":{"id":"kwrd0050"} "$$":[{"#name":"text" "_":"Appendicular Lean Mass Index BMI"} {"#name":"keyword" "$":{"id":"kwrd0060"} "$$":[{"#name":"text" "_":"Body Mass Index KE"} {"#name":"keyword" "$":{"id":"kwrd0070"} "$$":[{"#name":"text" "_":"Knee Extensors KF"} {"#name":"keyword" "$":{"id":"kwrd0080"} "$$":[{"#name":"text" "_":"Knee Flexors SPPB"} {"#name":"keyword" "$":{"id":"kwrd0090"} "$$":[{"#name":"text" "_":"Short Physical Performance Battery EWGSOP"} {"#name":"keyword" "$":{"id":"kwrd0110"} "$$":[{"#name":"text" "_":"European Working Group on Sarcopenia in Older People DXA"} {"#name":"keyword" "$":{"id":"kwrd0120"} "$$":[{"#name":"text" "_":"Dual-Energy X-ray Absorptiometry
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