Visceral adipose tissue quality was associated with nonalcoholic fatty liver disease,independent of its quantity |
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| Institution: | 1. Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan;2. Department of Internal Medicine, Matsushita Memorial Hospital, Osaka, Japan;3. Medical Corporation Soukenkai, Nishimura Clinic, Kyoto, Japan;1. Pediatric Endocrine and Diabetes Unit, Edmond and Lily Safra Children''s Hospital, Sheba Medical Center, Ramat Gan, Israel;2. Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel;3. IVF Unit, Sheba Medical Center, Ramat Gan, Israel;4. Child Development Center, Edmond and Lily Safra Children''s Hospital, Sheba Medical Center, Ramat Gan, Israel;5. The Danek Gertner Institute of Human Genetics, Sheba Medical Center, Ramat Gan, Israel;1. Division of Cardiology, Ospedale degli Infermi, ASL Biella, Biella, Italy;2. Department of Translational Medicine, Università del Piemonte Orientale, Novara, Italy;3. Clinical Chemistry Ospedale degli Infermi, ASL Biella, Biella, Italy;4. Dipartimento di Scienze della Sanità Pubblica e Pediatriche, Università degli Studi di Torino, Italy;5. Clinical Chemistry, Azienda Ospedaliera-Universitaria “Maggiore della Carità”, Università del Piemonte Orientale, Novara, Italy;6. Radiology, Azienda Ospedaliera-Universitaria “Maggiore della Carità”, Università del Piemonte Orientale, Novara, Italy;7. Division of Cardiology, Azienda Ospedaliera-Universitaria “Maggiore della Carità”, Università del Piemonte Orientale, Novara, Italy;1. Department of Non-communicable Disease Prevention, Nanjing Municipal Center for Disease Control and Prevention, Nanjing, 210003, China;2. Department of Non-communicable Chronic Disease Control, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, 210009, China;3. Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, 211166, China;4. Department of Chronic Disease Prevention and Control, Huai''an City Center for Disease Control and Prevention, Huai''an, 223001, China;5. Department of Chronic Disease Prevention and Control, Suzhou City Center for Disease Control and Prevention, Suzhou, 215003, China;6. Changshu County Center for Disease Control and Prevention, Suzhou, 215500, China;7. Department of Epidemiology and Biostatistics, School of Public Health, Southeast University, Nanjing, 210009, China;1. Adelaide Medical School, The University of Adelaide, Adelaide, Australia;2. Lyell McEwin Hospital, The University of Adelaide, Adelaide, Australia;3. Department of Cardiology and Vascular Medicine, University of Indonesia, Jakarta, Indonesia;4. Vascular Research Centre, Lifelong Health Theme, SAHMRI, Adelaide, Australia;5. Centre for Heart Rhythm Disorders, The University of Adelaide, Adelaide, Australia |
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| Abstract: | Background and aimsNonalcoholic fatty liver disease (NAFLD) is a serious liver disease. Recent studies have shown that both visceral adipose tissue (VAT) quantity and density (as an indirect measure of quality) are associated with metabolic profiles. Therefore, we investigated the association between VAT quantity and quality, and the prevalence and incidence of NAFLD.Methods and resultsIn this cross-sectional, retrospective cohort study, the prevalence and incidence of NAFLD were analyzed in 627 and 360 middle-aged subjects, respectively. VAT was evaluated using an unenhanced computed tomography scan, while NAFLD was evaluated using ultrasonography. The VAT area was normalized to the square value of the subjects’ height in meters, the visceral fat area (VFA) index. The VAT density was described as the visceral fat density (VFD). The VFA index and VFD had an interaction effect on the prevalence of NAFLD (P = 0.0059). The VFA index (adjusted odds ratio OR], 1.04; 95% confidence interval CI], 1.01–1.07; P = 0.0145, per 1.0 cm2/m2) and the VFD (OR, 0.90; 95% CI, 0.84–0.96; P = 0.0026, per 1.0 Hounsfield unit HU]) were independently associated with the prevalence of NAFLD. In our cohort, 36 subjects developed NAFLD. The VFD (adjusted hazards ratio HR], 0.84; 95% CI, 0.77–0.91; P < 0.0001, per 1.0 HU) was independently associated with the incidence of NAFLD, whereas the VFA index was not.ConclusionBoth the VFA index and VFD were independently associated with NAFLD prevalence. The VFD might be more related to the incidence of NAFLD than the VFA index. |
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| Keywords: | Nonalcoholic fatty liver disease Adipose tissue density Adipose tissue quality Adipose tissue quantity VAT"} {"#name":"keyword" "$":{"id":"kwrd0035"} "$$":[{"#name":"text" "_":"visceral adipose tissue VFA"} {"#name":"keyword" "$":{"id":"kwrd0045"} "$$":[{"#name":"text" "_":"visceral fat area VFD"} {"#name":"keyword" "$":{"id":"kwrd0055"} "$$":[{"#name":"text" "_":"visceral fat density NAFLD"} {"#name":"keyword" "$":{"id":"kwrd0065"} "$$":[{"#name":"text" "_":"nonalcoholic fatty liver disease |
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