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Dietary sugars and subclinical vascular damage in moderate-to-high cardiovascular risk adults |
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| Institution: | 1. Cardiovascular Prevention & Research Unit, Clinic & Laboratory of Pathophysiology, Department of Medicine, National and Kapodistrian University of Athens, Greece;2. Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University of Athens, Greece;3. Department of Food Science and Human Nutrition, Agricultural University of Athens, Greece;4. Hellenic Foundation for Cardiovascular Health and Nutrition, Athens, Greece;5. 1st Department of Propaedeutic and Internal Medicine & Joint Rheumatology Program, National and Kapodistrian University of Athens, Medical School, Greece;1. Center for Advancing Population Science (CAPS), Medical College of Wisconsin, Milwaukee, WI, USA;2. Department of Medicine, Division of General Internal Medicine, Medical College of Wisconsin, Milwaukee, WI, USA;1. China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China;2. Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China;3. Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China;4. Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China;5. Department of Cardiology, Kailuan Hospital, North China University of Science and Technology, China;6. Department of Neurological Intervention, Beijing Tiantan Hospital, Capital Medical University, Beijing, China;1. Unit of Cardiovascular Sciences, Department of Medicine, Campus Bio-Medico University of Rome, Rome, Italy;2. Unit of Food Science and Nutrition, Department of Science and Technology for Humans and the Environment, Campus Bio-Medico University of Rome, Rome, Italy;1. Laboratory of Exercise Physiology, Faculty of Physical Education, University of Campinas, Campinas, São Paulo, Brazil;2. Department of Physical Education, State University of Maringa, Maringa, Brazil;3. Department of Physical Education, University of Parana, Curitiba, Brazil;4. Federal Institute of Education, Science and Technology of São Paulo, Hortolandia Campus, Hortolandia, Brazil;1. Laboratorio de Lípidos y Aterosclerosis, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Argentina;2. Servicio de Nutrición y Diabetes, Hospital de Niños “Ricardo Gutiérrez”, Buenos Aires, Argentina;3. Laboratorio Central, Hospital de Niños “Ricardo Gutiérrez”, Buenos Aires, Argentina;4. Laboratorio Central, Hospital Italiano de Buenos Aires, Argentina |
| Abstract: | Background and aimsThe association between dietary sugars and vascular damage has been scarcely examined out of the context of established cardiovascular disease. We aimed to investigate the association between different types of sugars with subclinical atheromatosis and arteriosclerosis, in individuals free of cardiovascular disease being, however, at moderate-to-high cardiovascular risk.Methods and resultsTwo 24-h dietary recalls were conducted to estimate sugars intake. Subclinical atheromatosis was assessed by B-mode ultrasonography and arteriosclerosis (arterial stiffness) via tonometry (carotid-to-femoral pulse wave velocity). Multiple logistic regression analysis was performed to determine the relationship of quartiles of total sugars, monosaccharides and disaccharides with atheromatosis and arteriosclerosis, adjusting for potential confounders Odds Ratio (95%Confidence Interval)]. In 901 participants (52.4 ± 13.8 years, 45.2% males), total sugars intake was not associated with any type of subclinical vascular damage. Subjects at 4th quartile of lactose intake (15.3 ± 5.5 g/day) had lower probability to present atheromatosis compared to those at 1st quartile (0.00 ± 0.01 g/day) even in the fully adjusted model 0.586 (0.353–0.974)]. Subjects at 3rd quartile of total disaccharides intake and particularly sucrose (15.1 ± 2.2 g/day) had higher probability to present arteriosclerosis compared to those at 1st quartile (3.0 ± 1.9 g/day) even after adjustment for all potential confounders 2.213 (1.110–4.409)].ConclusionsOverall, the present data suggest a distinct role of each type of sugars on vascular damage. These observations highlight the need for further studies investigating not only foods rich in sugars, but sugars as separate components of food as they probably contribute via different ways on the development of arterial pathologies. |
| Keywords: | Dietary sugars Monosaccharides Disaccharides Atheromatosis Arterial stiffness Subclinical vascular damage MONO"} {"#name":"keyword" "$":{"id":"kwrd0045"} "$$":[{"#name":"text" "_":"Monosaccharides DIS"} {"#name":"keyword" "$":{"id":"kwrd0055"} "$$":[{"#name":"text" "_":"Disaccharides GLU"} {"#name":"keyword" "$":{"id":"kwrd0065"} "$$":[{"#name":"text" "_":"Glucose GAL"} {"#name":"keyword" "$":{"id":"kwrd0075"} "$$":[{"#name":"text" "_":"Galactose FRU"} {"#name":"keyword" "$":{"id":"kwrd0085"} "$$":[{"#name":"text" "_":"Fructose LAC"} {"#name":"keyword" "$":{"id":"kwrd0095"} "$$":[{"#name":"text" "_":"Lactose MAL"} {"#name":"keyword" "$":{"id":"kwrd0105"} "$$":[{"#name":"text" "_":"Maltose SUC"} {"#name":"keyword" "$":{"id":"kwrd0115"} "$$":[{"#name":"text" "_":"Sucrose cfPWV"} {"#name":"keyword" "$":{"id":"kwrd0125"} "$$":[{"#name":"text" "_":"Carotid-femoral pulse wave velocity CV"} {"#name":"keyword" "$":{"id":"kwrd0135"} "$$":[{"#name":"text" "_":"Cardiovascular |
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