北京协和医院肺栓塞基础病因的变迁

目的 进一步提高对肺栓塞的认识及探讨50年来北京协和医院肺栓塞基础病因的变迁。方法 对北京协和医院1950－2000年诊断的239例肺栓塞病例进行回顾性分析。结果 1950－1982年和1983-1990年两个时期内，北京协和医院每年平均诊断肺栓塞约3例，1991－1997年和1998－2000年两个时期内，每年平均诊断肺栓塞病例分别为8例和20.6例。四个不同时期内肺栓塞主要基础病因（深静脉血栓形态、心脏病、恶性肿瘤、结缔组织疾病）在同期肺栓塞病例中的发生率现在已有明显变化。深静脉血栓形成合并肺血栓栓塞症的发病较前有所增加。结论 当前肺栓塞的发病有增加趋势，深静脉血栓形成已成为肺栓塞的最主要的基础病因。

Trends of underline diseases of pulmonary embolism from Peking Union Medical College Hospital

OBJECTIVE: To highlight the understanding of pulmonary embolism(PE), and analyze the trends of underline diseases of PE from Peking Union Medical College(PUMC) Hospital in the last half century. METHODS: 239 cases of PE were reviewed retrospectively from 1950 to 2000 in PUMC Hospital. RESULTS: In the first and second periods (1950-1982, 1983-1990), about 3 cases of PE were diagnosed annually, but in the third (1991-1997) and fourth periods (1998-2000), 8 cases and 20.6 cases of PE were found annually. The incidence of underline diseases of PE, such as deep venous thrombosis (DVT), cardiac disease, malignancy and connective tissue disease varied in different periods. The morbidity of DVT with PE was dramatically enhanced recently. CONCLUSION: There is an increasing trend of incidence of PE in the last half century. DVT events become the most common underline disease or risk factor of PE.