| 冠心宁注射液对大鼠缺血再灌注心肌的保护作用研究 |
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| 引用本文： | 余浩,王祥,涂远超,陈苏,何传飞,李松南.冠心宁注射液对大鼠缺血再灌注心肌的保护作用研究[J].心血管康复医学杂志,2010,19(1):91-93. |
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| 作者姓名： | 余浩 王祥 涂远超 陈苏 何传飞 李松南 |
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| 作者单位： | 1. 湖北省新华医院心内科,湖北,武汉,430015
2. 华中科技大学附属协和医院心内科 |
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| 摘 要： | 目的:探讨冠心宁注射液对大鼠缺血再灌注心肌的影响。方法:40只SD大鼠被随机分为四组,每组10只,分别为:假手术组、梗塞对照组、冠心宁注射液低剂量组、冠心宁注射液高剂量组。采用结扎冠状动脉左前降支的方法复制急性心肌缺血再灌注模型,观察大鼠急性心肌梗塞范围、梗塞心肌组织细胞因子白细胞介素(IL)-10、肿瘤坏死因子(TNF)-α的水平。结果:(1)冠心宁注射液低、高剂量组心肌梗塞范围均显著小于梗塞对照组(P0.01),两剂量组之间无显著差异(P0.05);(2)冠心宁注射液低、高剂量组IL-10水平高于梗塞对照组(P0.05),低于假手术组(P0.01);TNF-α水平低于梗塞对照组(P0.05),高于假手术组(P0.01),而两剂量组之间无显著差异(P均0.05)。结论:冠心宁注射液能抑制大鼠坏死心肌TNF-α的表达,促进IL-10的生成,抑制炎症反应,减少心肌梗塞范围,具有较好的心肌保护作用。
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| 关 键 词： | 心肌梗塞 心肌缺血 再灌注损伤 |
Protective effects of guanxinning injection on myocardial ischemia/reperfusion injury in rats |
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| YU Hao,WANG Xiang,TU Yuan-chao,CHEN Su,HE Chuan-fei,LI Song-nan.Protective effects of guanxinning injection on myocardial ischemia/reperfusion injury in rats[J].Chinese Journal of Cardiovascular Rehabilitation Medicine,2010,19(1):91-93. |
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| Authors: | YU Hao WANG Xiang TU Yuan-chao CHEN Su HE Chuan-fei LI Song-nan |
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| Institution: | YU Hao,WANG Xiang,TU Yuan-chao,CHEN Su,HE Chuan-fei,LI Song-nan Department of Cardiology,Hubei Xinhua Hospital,Wuhan,Hubei,430015,China |
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| Abstract: | Objective:To study the protective effect of Guanxinning injection on myocardial ischemia/reperfusion injury in rats.Methods:A total of 40 SD rats were randomly divided into four groups,each with 10 rats(including two rats were used in paintings and the other eight used in experiment observation from each group).Four groups were as follows:sham operation group,the infarction control group,Guanxinning injection of low-dose group,Guanxinning injection of high-dose group.The model of acute myocardial ischemia r... |
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| Keywords: | Myocardial infarction Myocardial ischemia Reperfusion injury |
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