慢性心力衰竭患者血红细胞压积与脑钠肽关系的临床观察

目的：探讨慢性心力衰竭患者的血红细胞压积（HCT）与脑钠肽（BNP）的关系。方法：入选在我院心内科治疗的非瓣膜性慢性心衰的患者110例,采用回顾性横断面研究,根据左室射血分数（LVEF）值分成3组：LVEF〈40%组（心衰Ⅰ组,37例）、40%≤LVEF〈50%组（心衰Ⅱ组,34例）和LVEF≥50%组（心衰Ⅲ组,39例）（舒张性心衰）;另选30例LVEF〉50%且无心衰症状的患者作为正常对照组,检测各组HCT和BNP水平,并进行比较分析。结果：与正常对照组患者比较,慢性心衰Ⅲ、Ⅱ、Ⅰ组患者随着LVEF水平降低,HCT（41.1±2.7）%比（35.4±3.7）%比（32.9±1.5）%比（29.8±4.2）%]水平明显降低（P均〈0.05）,BNP（182.3±86.8）pg/ml比（652.8±151.3）pg/ml比（874.2±201.8）pg/ml比（1342.2±325.1）pg/ml]水平明显升高（P均〈0.01）;Pearson直线相关分析显示,HCT与BNP呈负相关（R2=0.6716,P〈0.01）。结论：慢性心力衰竭患者血红细胞压积水平与心衰严重程度有关,与脑钠肽呈负相关,血红细胞压积可以作为心衰的预测指标。

Correlation between hematocrit and brain natriuretic peptide in patients with chronic heart failure

Objective：To explore the correlation between hematocrit（HCT）and brain natriuretic peptide（BNP）in patients with chronic heart failure（CHF）.Methods：A total of 110patients with non-valvular CHF who received treatment in department of cardiology of our hospital were enrolled.Retrospective cross-sectional study was used,according to left ventricular ejection fraction（LVEF）,patients were divided into LVEF＆lt;40% group（CHF group Ⅰ,n=37）,40%≤LVEF＆lt;50% group（CHF groupⅡ,n=34）and LVEF≥50% group（CHF groupⅢ,n=39,diastolic heart failure）;another 30cases with LVEF＆gt;50%and no symptoms of heart failure were regard as normal control group.Levels of HCT and BNP were measured,compared and analyzed among all groups.Results：Compared with normal control group,there was significant decrease in HCT（41.1±2.7）% vs.（35.4±3.7）% vs.（32.9±1.5）%vs.（29.8±4.2）%],P＆lt;0.05all,and significant increase in BNP level（182.3±86.8）pg/ml vs.（652.8±151.3）pg/ml vs.（874.2±201.8）pg/ml vs.（1342.2±325.1）pg/ml],P＆lt;0.01all,in CHF groupⅢ,Ⅱ,Ⅰ;Pearson rectilinear correlation analysis indicated that HCT was negatively correlated with BNP（R2= 0.6716,P＆lt;0.01）.Conclusion：Hematocrit level is related with severity of heart failure and negatively correlated with brain natriuretic peptide in patients with chronic heart failure and can be used as predictor for heart failure.