健康管理对eNOS基因G894T突变人群高血压病发病风险的作用

目的：探讨健康管理对内皮型一氧化氮合成酶（eNOS）基因G894T突变人群高血压病发病风险的作用。方法：从2010年6月～2013年6月在山东省青岛疗养院体检和休养的人员以及青岛大学医学院附属医院就诊的病人中，通过基因芯片检测的方法，筛选360例45～60岁，eNOS基因G894T突变无高血压病人群为研究对象，根据依从性好坏分为健康管理组（163例）和对照组（197例，延续原有的生活方式）进行临床观察。两组均跟踪随访2年，对比高血压发生率以判断近期效果。结果：经过两年的跟踪随访，健康管理组163人中有17人（10．43％）被诊断患有高血压病；对照组197人中有49人（24．87％）被诊断为高血压病。健康管理组高血压发病率显著低于对照组（X^2=12．43，P=0．001）。结论：科学的健康管理能有效降低eNOS基因G894T突变人群的高血压发病率。

Effect of health management on morbidity risk of hypertension in population with eNOS gene G894T mutation

Objective： To explore the effect of health management on morbidity risk of hypertension in population with endotheliocyte nitric oxide synthetase （eNOS） gene G894T mutation. Methods： A total of 360 cases, who were 45~60 years old and possessed eNOS gene G894T mutation but without hypertension, were screened using gene chips detection from people who received physical examination and recreation in Qingdao sanatorium and patients visiting to affiliated hospital of medical college of Qingdao University from Jun 2010 to Jun 2013. According to their compli- ance condition, they were divided into health management group （n = 163） and control group （n = 197, continued their intrinsical lifestyle）. Both groups were followed up for two years, and their incidence rates of hypertension were compared. Results： After two-year follow-up, a total of 17 cases （10.43%） were diagnosed as hypertension a- mong 163 cases of health management group; it was significantly lower than that in control group （24.87%, X^2 = 12.43, P=0. 001）. Conclusion： Scientific health management can effectively reduce incidence rate of hypertension in population with eNOS gene G894T mutation.