| 人及小鼠白内障晶状体上皮细胞凋亡的超微结构 |
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| 作者姓名： | Chen F Chen C Song X |
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| 作者单位： | 首都医科大学!100054(陈凤华),北京市眼科研究所(陈翠真!100005),首都医科大学附属北京同仁医院眼科(宋旭东) |
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| 基金项目： | 国家自然科学基金资助项目!(39770786) |
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| 摘 要： | 目的 探讨人老年性白内障及小鼠先天性白内障与其晶状体上皮细胞凋亡的关系。方法 用透射电镜观察４例老年性白内障患者及２例先天性白内障小鼠晶状体上皮细胞凋亡的超微结构,并分别与同类正常晶状体上皮细胞超微结构进行比较。结果 老年性白内障患者及先天性白内障小鼠晶状体上皮细胞中均可见凋亡细胞,而正常晶状体未见凋亡细胞。结论 人老年性白内障及小鼠先天性白内障的发生均与其晶体上皮细胞的凋亡有关。
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| 关 键 词： | 白内障 晶状体上皮细胞 细胞凋亡 超微结构 |
The ultrastructure of human and mouse cataractous lens epithelial cell apoptosis |
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| Chen F,Chen C,Song X.The ultrastructure of human and mouse cataractous lens epithelial cell apoptosis[J].Chinese Journal of Ophthalmology,2000,36(2):107-108,I010. |
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| Authors: | Chen F Chen C Song X |
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| Institution: | Beijing Institute of Ophthalmology, Beijing 100005, China. |
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| Abstract: | Objective To observe the relation between human senile cataract, mouse congenital cataract and lens epithelial cell apoptosis Methods Transmission electron microscope was used to observe the apoptotic morphology of the lens epithelial cells in 4 cases with senile cataract and in 2 mice with congenital cataract The comparisons were made between the cataractous and normal transparent lens epithelial cells in human being and mice Results The apoptotic cells were found in senile cataract and mouse congenital cataract lens epithelial cells, while in all control lens epithelial cells they were few Conclusion Lens epithelial cells apoptosis is related to senile cataract and mouse congenital cataract formation |
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| Keywords: | Cataract Lens crystalline Epithelial cells Apoptosis |
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