蚕蚀性角膜溃疡的临床特点分析

探讨蚕蚀性角膜溃疡患者的临床特点和比较治疗方法的效果。方法对连续治疗的蚕蚀性角膜溃疡患者５５０例的患病年龄,性别,眼别,溃疡部位,溃疡穿孔,溃疡复发情况,以及球结膜切除术,板层角膜移植术及板层角膜移植术联环孢霉素Ａ滴眼的疗效进行分析情况,以及球结膜切除术,板层角膜移植术及板层角膜术联合环孢霉素Ａ滴眼的疗效进行分析。结果平均患病年龄４８．４岁;男：女之比为１：０．７４;双眼患病者１６５例,其中青年患

A clinical analysis of Mooren's corneal ulcer

OBJECTIVE: To investigate the clinical characteristics and to compare the effects of several therapies of Mooren's corneal ulcer. METHODS: 550 consecutive in-patients with Mooren's corneal ulcer were clinically analyzed, including the age, sex, laterality of the eye, ulcer location, rate of perforation, cure rate of surgeries, recurrent rate, and the effects of conjunctiva excision, lamellar keratoplasty (LKP), LKP plus cyclosporin A eye drops. RESULTS: The average age of onset of the ulcer was 48.4 years old, the ratio of male to female was 1:0.74, bilateral disease occurred in 165 cases (30.0%) of whom 52 cases (31.5%) were in the younger group and 113 (68.5%) in the older group. There were 501 eyes (70.1%) with the ulcer located at the limbus of palpebral fissure, and 95 out of 715 eyes with the disease had corneal perforation, the rate of perforation being 13.3%, 41 cases (43.2%) in the younger group and 54 cases (56.8%) in the older group. The postoperative recurrent rate was 25.6%. The cure rate of once LKP plus cyclosporin A eye drops was 73.7%, the final cure rate was 95.6%, and the preservative rate of the corneal anatomical structure of the surgeries was 99.7%. CONCLUSION: LKP plus cyclosporin A eye drops is an effective treatment of Mooren's corneal ulcer.