异佛司可林和佛司可林对兔高眼压模型的降眼压作用

探讨异佛司可林（ｉｓｏｆｏｒｓｋｏｌｉｎ，ｉｓｏＦ）和佛司可林（ｆｏｒｓｋｏｌｉｎ，ＦＳＫ）悬液眼对眼压增高（ｏｃｕｌａｒ ｈｙｐｅｒｔｅｎｔｉｏｎ，ＯＨＴ）的作用，并观察药物的局部刺激性。方法选用自发（１１只）和水负荷（３６只）ＯＨＴ兔，以气动式眼压计测量眼压，并评价药物作用，同时记录刺激性反应。

Suppressing effect of isoforskolin and forskolin on ocular hypertension in rabbits

Objective To examine the effects of isoforskolin (isoF) and forskolin (FSK) suspensions administered topically on eyes with ocular hypertension (OHT) and observe the local irritation of the drugs Methods The intraocular pressure (IOP) was measured with pneumotonometer in screened spontaneous or water loading induced OHT rabbits for evaluation of drug effects, and the irritation indices were recorded as well Results In screened OHT rabbits, isoF significantly lowered IOP from 0 5 to at least 4 5 h after the administration ( P <0 05, paired t test vs contralateral control eyes), with the maximum decreases of 0 25% and 1% isoF reaching 8 1 mm Hg and 7 0 mm Hg (1 mm Hg=0 133 kPa) at about 1 5 h later, respectively In water loaded OHT rabbits, both 0 06%, 0 1%, 0 25%, 1% isoF and 1%FSK concentration dependently suppressed the increments of IOP ( P <0 05 with the exception of 0 06% isoF) induced by water loading, and the peak effects of the optimal concentration of 0 25% isoF and 1% FSK were 7 1 and 6 9 mm Hg (difference of IOP between bilateral eyes) respectively The results also indicated that 0 25% isoF or FSK suspension had basically no irritation, but 1% induced slight irritating responses during the experiment Conclusion Both isoF and FSK had suppressing effects on OHT in rabbits with the optimal concentration being 0 25% and 1% respectively; at concentration of 0 25%, topically both drugs had basically no irritation, while 1% of the drugs may induce mild irritating responses