阿普可乐定防止Nd：YAG激光虹膜切除术后眼压升高

目的 了解阿普可乐定是否有效降低棕色虹膜人种激光肛膜切除术后眼压急性升高。方法 ４８只原发性闭角型青光眼,按年龄、性别进行匹配,分为治疗组和对照组。治疗组术前１小时和术后即刻滴用１％阿普可乐定,对照组滴用安慰剂。术后０．５、１．０、１．５、２．０、３．５小时观察眼压和其他情况。结果 激光治疗后,治疗组和对照组眼压最大升高值分别为０．６２±０．６７ｋＰａ（１ｋＰａ＝７．５ｍｍＨｇ）和１．１３±０．８

Apraclonidine prevents the acute increase of intraocular pressure in brown eyes with Nd:YAG laser iridectomy

OBJECTIVE: To investigate if apraclonidine can effectively prevent the acute increase of intraocular pressure (IOP) in brown eyes with Nd:YAG laser iridectomy. METHODS: 48 eyes with primary angle closure glaucoma were divided into treatment and control groups, which were matched by age and sex. One drop of apraclonidine was applied into the conjunctival sac at one hour before laser iridectomy and immediately after laser iridectomy in treatment group, whereas one drop of antibiotic as placebo was applied in control group at the same time. IOP, pupil diameter were measured at 0.5, 1, 1.5, 2, 3.5 hours after laser iridectomy. RESULTS: The maximum increase of IOP after laser iridectomy was 0.62 +/- 0.67 kPa and 1.13 +/- 0.87 kPa in treatment and control group respectively, there was a significant difference (P = 0.03). The obvious decrease of IOP occurred at 0.5, 1 and 1.5 hours after laser iridectomy in treatment group. No ocular and systemic side effects were found in treatment group, except pupil diameter was obviously larger in treatment group than that in control group. CONCLUSION: 1% apraclonidine effectively prevents the acute increase of IOP in brown eyes with Nd:YAG laser iridectomy.