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bcl-2基因和增殖细胞核抗原在人晶状体上皮细胞中的表达
作者姓名:Weng J  Zhang H
作者单位:1. 福建医科大学附属协和医院眼科,
2. 北京大学第三医院眼科
基金项目:本课题受福建省卫生厅科研基金资助(97033)
摘    要:目的:观察正常胚胎、儿童和老年人晶体上皮细胞中bcl-2基因和增殖细胞核抗原(proliferating cell nuchlear antigen,PCNA)的表达状况,探讨其与晶状体上皮细胞增殖潜能的关系。方法采用免疫组织化学染色法光谱下检测胚胎组(胎龄5-10个月)、儿童组(7个月至13岁)及老年组(>50岁)晶状体上皮细胞中bcl-2基因和PCNA的表达状况。结果:bcl-2基因和PCNA在胚胎组和儿童组晶状体上皮细胞中表达的阳性率显著高于老年组(P<0.01),且以晶状体赤道部明显,结论日 状体上皮细胞的增殖潜能以及后发性白内障的发生与晶状体上皮细胞内bcl-2基因及PCNA的表达有关。

关 键 词:bcl-2基因  增殖细胞核抗原  晶体  上皮细胞  白内障

The characteristics of bcl-2 and PCNA expression in the lens epithelium of human being
Weng J,Zhang H.The characteristics of bcl-2 and PCNA expression in the lens epithelium of human being[J].Chinese Journal of Ophthalmology,2001,37(3):197-199,T003.
Authors:Weng J  Zhang H
Institution:Department of Ophthalmology, Fujian Medical University, Fuzhou 350001, China.
Abstract:Objective To investigate the characteristics of bcl 2 (gene inhibiting apoptosis) and proliferating cell nuclear antigen (PCNA) expression and their relation to the proliferation of lens epithelium. Methods The expression of bcl 2 and PCNA were detected by immunohistochemical streptavidin peroxidase (SP) method. Results The expression of bcl 2 and PCNA in the lens epithelium of fetus and children was higher than that of the elderly, especially in the region of the lens equator. Conclusion The over expression of bcl 2 and PCNA in the lens epithelium of fetus and children suggests that bcl 2 and PCNA might be related to the development of cataract.
Keywords:Genes  bcl  2  Proliferating cell nuclear antigen  Lens  crystalline  Epithelial cells
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