Tamoxifen retinopathy |
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| Institution: | 1. Department of Ophthalmology, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran;2. Department of Hematology and Medical Oncology, Cancer Research Center, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran;3. Department of Research and Evaluation, Southern California Permanente Medical Group, Pasadena, CA, USA;4. Department of Clinical Science, Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, CA, USA;5. Eye Monitoring Center, Kaiser Permanente Southern California, Baldwin Park, CA, USA;1. Department of Ophthalmology, University Medical Center Utrecht, Utrecht, the Netherlands;2. Department of Ophthalmology, Amsterdam University Medical Centers, Amsterdam, the Netherlands;3. Department of Human Genetics, Section Ophthalmogenetics, Amsterdam University Medical Centers, Amsterdam, the Netherlands;4. Queen Emma Center of Precision Medicine, Amsterdam University Medical Centers, Amsterdam, the Netherlands;5. Department of Ophthalmology, Leiden University Medical Center, Leiden, the Netherlands;6. Diagnostic Center for Complex Visual Disorders, Zeist, the Netherlands;1. Wills Eye Hospital, Mid Atlantic Retina, Thomas Jefferson University, Philadelphia, PA, USA;2. Retina and Vitreous of Texas, Methodist Hospital Blanton Eye Institute, Baylor College of Medicine Cullen Eye Institute, Houston, TX, USA;3. Department of Ophthalmology, Shiley Eye Institute, University of California, San Diego, CA, USA;4. Department of Ophthalmology, Institute of Ophthalmology, Giza, Egypt;5. The Retina Eye Center, Cairo, Egypt;1. Department of Ophthalmology, São Paulo Federal University, São Paulo, SP, Brazil;2. Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA;3. University of the Philippines College of Medicine, Manila, Philippines;4. Department of Biostatistics, Harvard TH Chan School of Public Health, Boston, MA, USA;5. Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA;6. Joslin Diabetes Center, Harvard Medical School, Beetham Eye Institute, Boston, MA, USA;7. Philippine Eye Research Institute, University of the Philippines, Manila, Philippines;8. Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA;9. Vision Institute, Instituto Paulista de Estudos e Pesquisas em Oftalmologia (IPEPO), São Paulo, SP, Brazil;1. Hoopes Vision Research Center, Hoopes Vision, Draper, UT, USA;2. John A. Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT, USA;3. Utah Lions Eye Bank, Murray, UT, USA;4. University of Utah School of Medicine, Salt Lake City, UT, USA;1. Baylor College of Medicine, Houston, Texas, USA;2. Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, USA;3. Department of Pathology, Texas Children''s Hospital, Houston, Texas, USA;4. Department of Ophthalmology, Baylor College of Medicine, Houston, Texas, USA;5. Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA |
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| Abstract: | Tamoxifen (TAM) is a selective estrogen receptor modulator that is used in the treatment of breast cancer. As there are estrogen receptors in the retina, retinal pigment epithelium, and choroid, these tissues may also be affected by TAM. We describe the reported effects of TAM on the retina and choroid. Medical databases were searched using relevant keywords and the results were extracted and pooled. The incidence of retinal/choroidal toxicity ranged from 0.9% to 12%. There was a wide range for the time of exposure before the development of TAM retinopathy (3 weeks to 13 years). While functional measurements may be appropriate for assessment of TAM retinopathy, they have not been effective for screening patients. There is no generally accepted screening modality, but serial funduscopy and optical coherence tomography imaging seem to be the most reasonable approach for detecting early TAM-induced retinal toxicity. |
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