| 大鼠外伤性PVR中胶质纤维酸性蛋白免疫组织化学观察 |
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| 引用本文： | 姜曦,张效房,叶诸榕,张月娥. 大鼠外伤性PVR中胶质纤维酸性蛋白免疫组织化学观察[J]. 中华眼底病杂志, 1995, 0(4) |
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| 作者姓名： | 姜曦 张效房 叶诸榕 张月娥 |
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| 作者单位： | 河南医科大学第一附属医院眼科，上海医科大学病理教研室 |
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| 摘 要： | 对大鼠眼后段芽通伤所致的外伤性增殖性玻璃体视网膜病变（ＰＶＲ）形成过程中视网膜Ｍｕｌｌｅｒ细胞的胶质纤维酸性蛋白（ＧＦＡＰ）免疫活性改变及神经胶质细胞移行分布进行动态观察。伤后３天，Ｍｕｌｌｅｒ细胞ＧＦＡＰ阳性染色开始增强；第７天，整个视网膜Ｍｕｌｌｅｒ细胞呈ＧＦＡＰ阳性着色；１４天即可见有神经胶质细胞出现于视网膜前增生纤维组织中；第２１及２８天，在观网膜前及穿通伤口的增生纤维组织中可见大量视网膜神经胶质细胞存在，提示反应性星形胶质化是ＰＶＲ的主要病变基础，是造成视网膜损害的重要原因。
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| 关 键 词： | 视网膜疾病／病理学，免疫组织化学，眼损伤，穿通性疾病模型，动物 |
AN IMMUNOHISTOCHEMICAL SURVEY OF GLIAL FIBRILLARY ACIDICPROTEIN ON TRAUMATIC PROLIFERATIVE VITREORETINOPATHY IN RAT |
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| Jiang Xi, Zhang Xiaofang, Ye Zhurong,et al.. AN IMMUNOHISTOCHEMICAL SURVEY OF GLIAL FIBRILLARY ACIDICPROTEIN ON TRAUMATIC PROLIFERATIVE VITREORETINOPATHY IN RAT[J]. Chinese Journal of Ocular Fundus Diseases, 1995, 0(4) |
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| Authors: | Jiang Xi Zhang Xiaofang Ye Zhurong et al. |
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| Abstract: | The dynamic changes of glial fibrillary acidic protein (GFAP)immunoreactivity weredetermined on the rat retina with proliferative vitroretinopathy caused by penetrating injury on pos-terior segment of the eyeball.On the third day after insult,the Muller cell showed enhanced GFAPimmunoreactivity,while on the seventh day GFAP positive processes of Muller cells extended of thewhole thickness of the retina. Retinal glial cells appeared into the pre-retinal membrane and becameproliferated and GFAP positive from forteenth to twenty-eighth day, forming a pre-retinal glialfi-brous scar. The result suggests that reactive astrogliosisis the main event of proliferative vlt-roretinopathy and is the important cause of retinal damage. |
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| Keywords: | Retinal diseases/pathology Immunohistochemistry Eye injuries penetrat-ing Disease models animal |
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