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血栓通联合等容血液稀释治疗视网膜静脉阻塞对纤溶活性及血液流变学的影响
引用本文:席兴华,谭家铨,聂爱光,姜德咏,曾耀星.血栓通联合等容血液稀释治疗视网膜静脉阻塞对纤溶活性及血液流变学的影响[J].中华眼底病杂志,1998,14(1):7-9.
作者姓名:席兴华  谭家铨  聂爱光  姜德咏  曾耀星
作者单位:410011 长沙,湖南医科大学附属第二医院眼科(席兴华、谭家铨、聂爱光、姜德咏),输血科(曾耀星)
摘    要:目的探讨血栓通(panax notoginsang saponins,PNS)、等容血液稀释(isovalaemic haemodilution,IHD)以及二者联合治疗视网膜静脉阻塞(retinal vein occlusion,RVO)的效果。方法采用PNS、IHD及二者联合随机对照治疗RVO患者73例,观察治疗前后患者血浆组织型纤溶酶原激活物(tissue plasminogen activator,t-PA)及其抑制物(plasminogen activator inhibitor,PAI)活性、血液流变学参数及视力的改变。结果治疗结束时,PNS+IHD组和PNS组较治前t-PA活性增高;PAI活性降低;IHD组t-PA活性和PAI活性改变不明显;除IHD组血浆粘度变化不明显外,三组患者血液流变学指标均有不同程度改善。治疗后1个月,PNS+IHD组全血低切粘度、低切还原粘度和红细胞聚集指数及其聚集力较治疗前仍有显著差异;且视力改善亦较快、较好。结论PNS联合IHD治疗RVO具有调节机体纤溶功能和较持久地降低血液粘度,提高治疗效果的作用。(中华眼底病杂志,1998,14:7-9)

关 键 词:视网脉静脉阻塞  血栓通  等容血液稀释
收稿时间:1997-07-09

The effect of combined treatment of xue-shuan-tong and isovalaemic haemodilution on activities of fibrinolysis and hemorrheology in patients with retinal vein occlusion
Xi Xing-hua,Tan Jia-quan,Nie Ai-guang,et al.The effect of combined treatment of xue-shuan-tong and isovalaemic haemodilution on activities of fibrinolysis and hemorrheology in patients with retinal vein occlusion[J].Chinese Journal of Ocular Fundus Diseases,1998,14(1):7-9.
Authors:Xi Xing-hua  Tan Jia-quan  Nie Ai-guang  
Institution:Department of Ophthalmology,Second Affiliated Hospital,Hunan Medical University,Changsha 410011,China
Abstract:ObjectiveTo explore the effect of xue-shuan-tong(panax notoginsang saponins,PNS)or isovalaemic haemodilution(IHD)and PNS combining IHD treatment on activities of fibrinolysis and hemorrheology in patients with retinal vein occlusion (RVO). MethodsSeventy-three patients with RVO were allocated at random to 3 groups which were treated with PNS,IHD and PNS combining IHD.The activities of t-PA and PAI,rheological parameters and visual acuity before and after treatment were observed. ResultsAt the end of treatment,significantly increased activity of t-PA and decrease of PAI was found in combined treatment group and PNS group,but the difference before and after treatment was not significant in IHD group.Furthermore,except the plasma viscosity in IHD group,the other hemorrheological parameters in all the petients of 3 groups revealed to be improving.One month after treatment,the parameters return completely to normal in both PNS and IHD groups; while the whole blood apparent relative viscosity in low shear rate,RBC aggregation and RBC deformability maintained still in lower level,and also the visual acuity resumed better and quicker in combined group. ConclusionCombined treatment of PNS and IHD can both regulate the activity of fibrinolysis and decrease the blood viscosity of patients with RVO for a period of relatively long time and increase the effect of treatment. (Chin J Ocul Fundus Dis,1998,14:7-9)
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