| Intracameral anti-VEGF injection for advanced neovascular glaucoma after vitrectomy with silicone oil tamponade |
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| 作者姓名： | Ling Bai Farheen Tariq Yi-Dan He Shu Zhang Feng Wang |
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| 作者单位： | 1Department of Ophthalmology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China |
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| 基金项目： | Supported by the Natural Science Foundation of Shaanxi Province (No.2017JM8032)。 |
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| 摘 要： | AIM: To evaluate the effect of intracameral injection of conbercept for the treatment of advanced neovascular glaucoma(NVG) after vitrectomy with silicone oil tamponade.METHODS: Conbercept 0.5 mg/0.05 m L was injected into the anterior chamber of 5 eyes, which had developed advanced NVG after vitrectomy with silicone oil tamponade. Then, trabeculectomy with mitomycin C and pan-retinal photocoagulation(PRP) or extra-PRP were conducted within 2 d. The follow-up time was 6 mo. Best-corrected visual acuity(BCVA), intraocular pressure(IOP), neovascularization of iris(NVI) were recorded before and after treatment.RESULTS: Within 2 d after injection, IOP control, and NVI regression were optimal for trabeculectomy. Hyphema occurred in one eye in the process of injection. But none of them present hyphema after trabeculectomy. At the end of follow-up time, all eyes had improved BCVA, well-controlled IOP, and completely regressed NVI. CONCLUSION: Intracameral injection of conbercept is safe and effective in the treatment of patients with advanced NVG after vitrectomy with silicone oil tamponade. Within 2 d after injection is the optimal time window for trabeculectomy, which can maximally reduce the risk of perioperative hyphema.
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| 关 键 词： | neovascular glaucoma anti-vascular endothelial growth factor therapy conbercept VITRECTOMY silicone oil |
| 收稿时间： | 2020/7/15 0:00:00 |
| 修稿时间： | 2020/9/21 0:00:00 |
Intracameral anti-VEGF injection for advanced neovascular glaucoma after vitrectomy with silicone oil tamponade |
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| Ling Bai,Farheen Tariq,Yi-Dan He,Shu Zhang,Feng Wang.Intracameral anti-VEGF injection for advanced neovascular glaucoma after vitrectomy with silicone oil tamponade[J].International Journal of Ophthalmology(English edition),2021,14(3):456-460. |
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| Authors: | Ling Bai Farheen Tariq Yi-Dan He Shu Zhang and Feng Wang |
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| Institution: | 1.Department of Ophthalmology, the Second Affiliated Hospital of Xi''an Jiaotong University, Xi''an 710003, Shaanxi Province, China;2.Experimental Teaching Center for Clinical Skills, the Second Affiliated Hospital of Xi''an Jiaotong University, Xi''an 710003, Shaanxi Province, China;3.Department of Geriatric Medicine, the Second Affiliated Hospital of Xi''an Jiaotong University, Xi''an 710003, Shaanxi Province, China |
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| Abstract: | AIM: To evaluate the effect of intracameral injection of conbercept for the treatment of advanced neovascular glaucoma (NVG) after vitrectomy with silicone oil tamponade.
METHODS: Conbercept 0.5 mg/0.05 mL was injected into the anterior chamber of 5 eyes, which had developed advanced NVG after vitrectomy with silicone oil tamponade. Then, trabeculectomy with mitomycin C and pan-retinal photocoagulation (PRP) or extra-PRP were conducted within 2d. The follow-up time was 6mo. Best-corrected visual acuity (BCVA), intraocular pressure (IOP), neovascularization of iris (NVI) were recorded before and after treatment.
RESULTS: Within 2d after injection, IOP control, and NVI regression were optimal for trabeculectomy. Hyphema occurred in one eye in the process of injection. But none of them present hyphema after trabeculectomy. At the end of follow-up time, all eyes had improved BCVA, well-controlled IOP, and completely regressed NVI.
CONCLUSION: Intracameral injection of conbercept is safe and effective in the treatment of patients with advanced NVG after vitrectomy with silicone oil tamponade. Within 2d after injection is the optimal time window for trabeculectomy, which can maximally reduce the risk of perioperative hyphema. |
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| Keywords: | chopping in cataract simulator wet-lab |
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