可溶性血管内皮生长因子受体-2及其对眼新生血管抑制作用的研究进展

新生血管形成是很多重要眼部疾病的共同病理改变，血管内皮生长因子（vascularendo-thelialgrowthfactor，VEGF）是血管生成重要的促进因子。近年来，可溶性血管内皮生长因子受体-2（solubleVEGFreceptor-2，sVEGFR-2）被证实为一种VEGF促血管生成信号转导通路的天然抑制剂。有研究表明，它与眼部新生血管的发生发展密切相关，可作为新生血管性眼病的抑制因子及其血清标志物而具有临床应用价值。本文就sVEGFR-2在抗眼部新生血管中作用的研究进展予以综述。

Soluble vascular endothelial growth factor receptor-2 and its inhibitory effects on ocular neovascularization

Angiogenesis is the main pathologic change in many important ocular diseases, and vascu lar endothelial growth factor （VEGF） is the crucial angiogenic stimulator. In recent years, soluble vascular endothelial growth factor receptor2 （sVEGFR2） has been proved to be a native inhibitor of the angiogenesis and signal transduction pathways induced by VEGF. Studies indicated that sVEGFR2 had intimate connec tion with the occurance and progression of ocular angiogenesis, and could be regarded as an inhibitory factor as well as surrogate marker of neovascular eye diseases, which implies a potential clinical practice. This re view focuses on the recent advances of the inhibitory effects of sVEGFR2 on the ocular neovascularization.