| 全反式维甲酸在眼表疾病中应用的研究进展 |
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| 引用本文： | 姚旺,乐琦骅.全反式维甲酸在眼表疾病中应用的研究进展[J].国际眼科纵览,2017,41(1). |
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| 作者姓名： | 姚旺 乐琦骅 |
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| 作者单位： | 复旦大学附属眼耳鼻喉科医院眼科, 上海,200031 |
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| 基金项目： | 国家自然科学基金(81270014)The National Natural Science Fund Projects of China |
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| 摘 要： | 全反式维甲酸(all-trans retinoid acid,ATRA)是维生素A的重要中间代谢物,其在调节眼部组织多种细胞的增生、分化以及维持上皮组织的正常角化等过程中均发挥重要作用.ATRA在角结膜瘢痕性病变如Stevens-Johnson综合征以及角膜损伤性疾病中可能具有独特的疗效,同时ATRA在抑制角膜移植术后的免疫排斥反应和治疗局部角膜缘干细胞缺乏症也具有良好的应用前景.
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| 关 键 词： | 全反式维甲酸 眼表疾病 |
All-trans retinoid acid and the ocular surface |
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| YAO Wang,LE Qi-hua.All-trans retinoid acid and the ocular surface[J].International Review of Opthalmology,2017,41(1). |
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| Authors: | YAO Wang LE Qi-hua |
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| Abstract: | All-trans retinoid acid (ATRA) is one of the vital metabolites of vitamin A.ATRA plays a crucial role in the regulation of cellular proliferation,differentiation,and normal keratinization of ocular surface epithelium.ATRA has a potential therapeutic effect against some ocular surface cicatricial disorders such as Stevens-Johnson syndrome and diseases associated with corneal epithelial damage.ATRA is a promising tool in the treatment of allogenic graft rejection after penetrating keratoplasty and partial limbal stem cell deficiency (LSCD). |
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| Keywords: | all-trans retinoid acid ocular surface disorder |
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