Cancer‐like metabolism of the mammalian retina |
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| Authors: | Soo Khai Ng MBBS John PM Wood DPhil Glyn Chidlow DPhil Guoge Han MBBS Thaksaon Kittipassorn MD Daniel J Peet PhD Robert J Casson DPhil FRANZCO |
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| Institution: | 1. South Australian Institute of Ophthalmology, University of Adelaide, Adelaide, South Australia, Australia;2. School of Molecular and Biomedical Science (Biochemistry), University of Adelaide, Adelaide, South Australia, Australia;3. Department of Physiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand |
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| Abstract: | The retina, like many cancers, produces energy from glycolysis even in the presence of oxygen. This phenomenon is known as aerobic glycolysis and eponymously as the Warburg effect. In recent years, the Warburg effect has become an explosive area of study within the cancer research community. The expanding knowledge about the molecular mechanisms underpinning the Warburg effect in cancer promises to provide a greater understanding of mammalian retinal metabolism and has motivated cancer researchers to target the Warburg effect as a novel treatment strategy for cancer. However, if the molecular mechanisms underlying the Warburg effect are shared by the retina and cancer, treatments targeting the Warburg effect may have serious adverse effects on retinal metabolism. Herein, we provide an updated understanding of the Warburg effect in mammalian retina. |
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| Keywords: | aerobic glycolysis HIF‐1 mammalian retina PKM2 Warburg effect |
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