普拉洛芬滴眼液对白内障手术患者视网膜结构及外周血VEGF表达的影响

目的：观察普拉洛芬滴眼液对白内障术后患者视网膜结构及外周血血管内皮生长因子(VEGF)表达的影响。

方法：选取2015-09/2016-09在我院接受手术治疗的白内障患者172例200眼，随机分为对照组和观察组，各86例100眼。对照组术后采用氟米龙滴眼液治疗，观察组在对照组基础上联合使用普拉洛芬滴眼液。观察两组患者术后炎症(角膜水肿、结膜充血)情况和视网膜结构\〖黄斑中心区视网膜厚度(MFRT)、黄斑中心凹视网膜厚度(CMT)、光感受器内外节连接层(IS/OS)厚度\〗，检测手术前后血清超氧化物歧化酶(SOD)、丙二醛(MDA)和VEGF水平。

结果：术后7、15、30d，对照组患者炎症评分、CMT水平均高于观察组，而IS/OS层厚度均低于观察组(P<0.001)。术后15、30d，对照组患者MFRT水平均高于观察组(P<0.001)。术后30d，两组患者血清SOD水平均明显上升，血清MDA和VEGF水平均明显下降(P<0.001)。

结论：普拉洛芬能够减轻白内障术后炎症，降低外周血VEGF表达，促进视网膜恢复。

Effects of Pranoprofen on the retinal structure and serum levels of VEGF in patients with cataract surgery

AIM: To evaluate the effects of pranoprofen on the retinal structure and serum levels of vascular endothelial growth factor(VEGF)in patients with cataract surgery.

METHODS: One hundred and seventy two cataract patients(200 eyes)were enrolled in this study. All the patients were randomly divided into observation group and control group. The patients of observation group were treated with pranoprofen combined with normal post-operative therapy for 1mo. We set 4 points(1d, 7d, 15d and 30d after surgery)to dynamically analyze the fluctuation of inflammation score, central macular retinal thickness(CMT), macular foveola retinal thickness(MFRT), and the light receptor inner segment and outer segment layer(IS/OS). We set two points(before and 30d after surgery)to dynamically observe the alteration of superoxide dismutase(SOD), malondialdehyde(MDA)and VEGF.

RESULTS: The levels of inflammation index in control group were higher than those in observation group 7d, 15d and 30d after surgery, respectively(P<0.001). The levels of CMT in control group were higher than those in observation group 15d and 30d after surgery, respectively(P<0.001). The levels of IS/OS in control group were lower than those in observation group 7d, 15d and 30d after surgery, respectively(P<0.001). Both of two groups expressed a markedly increasing of SOD levels(P<0.001)and decreasing of MDA and VEGF levels(P<0.001)30d after surgery compared with those before surgery. The levels of SOD in control group were lower than those in observation group(P<0.001), whereas the contents of MDA and VEGF in control group were higher than those in observation group(P<0.001)30d after surgery.

CONCLUSION: Pranoprofen considerably relieve levels of inflammation injury and down-regulate circulating levels of VEGF, which contributes its promotion in the recovery of retinal structure after surgery.