MMP-9、GA、HbA1c和脂肪因子水平与DR的相关性分析

目的:探讨基质金属蛋白酶-9(MMP-9)、糖化白蛋白(GA)、糖化血红蛋白(HbA1c)和脂肪因子(包括内脂素、抵抗素和瘦素)与糖尿病视网膜病变(DR)的相关性.方法:选取2015-03/2017-03在我院治疗的DR患者74例148眼,其中非增生性糖尿病视网膜病变患者(NPDR)40例80眼,增生性糖尿病视网膜病变患者(PDR)34例68眼,同时选取非DR单纯糖尿病患者(NDR)40例80眼以及健康志愿者40例80眼作为对照,检测各组MMP-9、GA、HbA1 c、内脂素、抵抗素和瘦素水平.结果:PDR组内脂素为4.41±0.82ng/mL,明显低于NPDR组、NDR和对照组(P<0.05),而抵抗素、瘦素和MMP-9分别为9.01±1.04 ng/mL、17.96±2.03μg/L和740.06±84.43μg/L,GA和HbA1c分别为26.14%±4.57%、17.60%±1.91%,明显高于NPDR组、NDR组和对照组(P<0.05);NPDR组内脂素为6.44±0.79ng/mL,明显低于NDR和对照组(P<0.05),而抵抗素、瘦素和MMP-9分别为7.80±0.87 ng/mL、15.68±1.98μg/L、634.12±80.22μg/L,GA和HbA1c分别为22.06%±4.38%、12.46%±1.69%,明显高于NDR组和对照组(P<0.05);MMP-9、GA、HbA1c与DR水平呈正相关(rs=0.523、0.461、0.414,P<0.05);内脂素与DR呈负相关(rs=-0.433,P<0.05),抵抗素和瘦素与DR水平呈正相关(rs=0.401、0.460,P<0.05).结论:MMP-9、GA、HbA1 c和脂肪因子可能在DR发生发展中有一定作用,其中MMP-9和脂肪因子有相关性,两者与GA、HbA1 c水平无明显关系.

Correlation of MMP-9, GA, HbA1c, and adipokines levels with DR

·AIM: To investigate the correlation of matrix metalloproteinase -9 (MMP-9), glycated albumin (GA), glycosylated hemoglobin ( HbA1c ) and adipokines ( including visfatin, resistin and leptin ) with diabetic retinopathy ( DR) .·METHODS:From March 2015 to March 2017, 74 patients with DR were treated in our hospital, including 40 patients ( 80 eyes ) with non proliferative diabetic retinopathy ( NPDR ) and 34 patients ( 68 eyes ) with proliferative diabetic retinopathy ( PDR ) , and diabetes mellitus 40 patients ( 80 eyes ) with non DR ( NDR ) and 40 healthy volunteers (80 eyes) were selected as controls, the levels of MMP-9, GA, HbA1c, visfatin, resistin and leptin in each group were detected.·RESULTS: PDR group visfatin was 4. 41 ± 0. 82ng/mL, was significantly lower than the NPDR group, NDR group and control group ( P<0. 05 ) , while, resistin, leptin and MMP- 9 were 9. 01 ± 1. 04ng/mL, 17. 96 ± 2. 03μg/L and 740. 06 ± 84. 43μg/L, GA and HbA1c were 26. 14%± 4. 57%and 17. 60% ± 1. 91%, significantly higher than those of NPDR group, NDR group and control group ( P<0. 05 ) . NPDR group visfatin was 6. 44 ± 0. 79ng/mL, was significantly lower than that of NDR group and control group (P<0. 05), while, resistin, leptin and MMP-9 were 7. 80±0. 87ng/ml, 15. 68±1. 98μg/L and 634. 12±80. 22μg/L,GA and HbA1c were 22. 06%± 4. 38% and 12. 46%± 1. 69%, significantly higher than those of NDR group and control group (P<0. 05). MMP-9, GA, HbA1c were positively with DR levels ( rs = 0. 523, 0. 461 and 0. 414, P<0. 05 );visfatin was negatively correlated with DR levels ( rs = -0. 433, P < 0. 05 ), resistin and leptin were positively correlated with DR levels (rs=0. 401 and 0. 460, P<0. 05).·CONCLUSION: MMP-9, GA, HbA1c, and adipokines may play a role in the development and progression of DR, in which MMP-9 is associated with adipokines, both are not significantly related to the levels of GA and HbA1c.