| 翼状胬肉发病机制的分子生物学研究进展 |
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| 引用本文： | 张莉薇,席兴华.翼状胬肉发病机制的分子生物学研究进展[J].国际眼科杂志,2006,6(6):1404-1406. |
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| 作者姓名： | 张莉薇 席兴华 |
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| 作者单位： | 410011,中国湖南省长沙市,中南大学湘雅二医院眼科 |
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| 摘 要： | 翼状胬肉是一种常见的眼表疾病,大量的流行病学研究显示其与紫外线的照射有关,但其确切的发病机制还不清楚,发病机制的研究是有效治疗和预防翼状胬肉发生和复发的关键,目前就国内外在细胞凋亡抑制、氧化应激、细胞因子和生长因子以及基质金属蛋白酶方面的研究进行综述。
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| 关 键 词： | 翼状胬肉 发病机制 P53 氧化应激 细胞因子 生长因子 基质金属蛋白酶 |
| 收稿时间： | 06 27 2006 12:00AM |
| 修稿时间： | 11 9 2006 12:00AM |
Advances in microbiological researches on the mechanism of pterygium |
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| Li-Wei Zhang,Xing-Hua Xi.Advances in microbiological researches on the mechanism of pterygium[J].International Journal of Ophthalmology,2006,6(6):1404-1406. |
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| Authors: | Li-Wei Zhang Xing-Hua Xi |
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| Institution: | Department of Ophthalmology, the Second Xiangya Hospital, Central-South University, Changsha 410011, Hunan Province, China |
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| Abstract: | Pterygium is a common ocular surface disorder.The increased incidence of pterygium is due to UV-B/sunlight exposure,but the underlying biological mechanisms have not been well understood.Understanding the biochemical process might be the key to treat and prevent pterygium and to decrease the recurrence rate.In this paper,the current knowledge on pterygium pathogenesis including anti-apoptotic mechanisms,cytokines,growth factors,oxidative stress and matrix metalloproteinases is summarized. |
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| Keywords: | pterygium pathogenesis P53 oxidative stress cytokines growth factors matrix metalloproteinases |
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