调体脱敏方加减内服配合眼部冷湿敷治疗过敏性结膜炎

目的:观察调体脱敏方加减内服配合眼部冷湿敷治疗过敏性结膜炎的临床疗效及对免疫功能的影响。方法:选择2020-07/2021-03经我院确诊的过敏性结膜炎患者160例320眼。将患者随机分为治疗组和对照组,治疗组80例160眼采用中药汤剂调体脱敏方加减内服配合眼部冷湿敷治疗,对照组80例160眼局部点0.05%氮卓斯汀滴眼液治疗。连续治疗14d后,观察两组症状体征评分、过敏性结膜炎生活质量问卷评分、血清免疫球蛋白IgG、IgA、IgE水平的变化。结果:两组患者症状体征评分和生活质量问卷评分均较治疗前有改善(P<0.05),且治疗组改善要优于对照组(P<0.05);两组血清免疫球蛋白IgG、IgA水平治疗前后无明显改善(P>0.05),治疗组治疗后IgE水平较治疗前有明显改善(P<0.05)。结论:调体脱敏方加减内服配合眼部冷湿敷治疗能改善过敏性结膜炎的临床症状,有助于缓解过敏反应,提高生活质量。

Observation on the curative effect of Tiaoti Tuomin Decoction on allergic conjunctivitis and the changes of immunologic function

AIM:To observe the curative effect of take oral and cold-wet compress on eyes with Tiaoti Tuomin Decoction and the changes of immunologic function in patients with allergic conjunctivitis.

METHODS:Totally 160 patients 320 eyes with allergic conjunctivitis were randomly divided into observation group and control group. The 80 patients(160 eyes)in the observation group were treated with Tiaoti Tuomin Decoction take oral and cold-wet compress on eyes. The 80 patients(160 eyes)in the control group were treated with 0.05% Azelastine Hydrochloride Eye Drops. After 14d of continuous treatment, the symptom and sign scores, quality of life questionnaire scores of allergic conjunctivitis, and the levels of serum immunoglobulin IgG, IgA, IgE of the two groups were compared and analyzed.

RESULTS:After treatment, the scores of symptom and sign, quality of life questionnaire of allergic conjunctivitis in both groups were better than those before treatment(P<0.05), and the improvement degree of which in the observation group was better than that in the control group(P<0.05). After treatment, the levels of serum immunoglobulin IgG, IgA in the two groups were not significant improvement than before treatment(P >0.05), the level of serum immunoglobulin IgE in the observation group were significantly improved than before treatment(P<0.05).

CONCLUSION: Treatment of take oral and cold-wet compress on eyes with Tiaoti Tuomin Decoction can improve clinical symptoms of allergic conjunctivitis patients, help relieve allergic reaction and improve the quality of life.