内皮-间质转化在眼部疾病中的研究进展

内皮-间质转化(endothelial-to-mesenchymal transition,EndoMT)是在生理或病理条件下,内皮细胞向间质细胞转化或分化,并伴随表型和功能的改变,是纤维修复的重要组成部分,广泛参与胚胎发育、肿瘤侵袭及多种纤维化疾病发展的病理生理过程,有关EndoMT在眼部疾病中作用的研究也取得一定进展。本文就EndoMT的基本生物学特性、发生机制和其在眼病中的相关研究进行综述,以期在理论上揭示其作为相关眼病治疗靶点及再生医学技术关键点的可能性,为临床工作及科学研究提供参考。

Research progress of endothelial-to-mesenchymal transition in ocular diseases

Endothelial-to-mesenchymal transition(EndoMT)is a change in the transformation or differentiation of endothelial cells into mesenchymal cells under physiological or pathological conditions, accompanied by changes in phenotype and function, and is an important part of fiber repair. It is widely involved in the pathophysiological process of embryonic development, tumor invasion and a variety of fibrotic diseases. Research on the role of EndoMT in ocular diseases has also made some progress. This article will review the basic biological characteristics, mechanism and research results of EndoMT in ophthalmological diseases, intending to theoretically reveal its possibility as a treatment target and a key point of regenerative medicine technology in related diseases, provide a reference for clinical practice and scientific research.