| TNF与糖尿病视网膜病变 |
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| 引用本文： | 姜文敏,唐罗生.TNF与糖尿病视网膜病变[J].国际眼科杂志,2007,7(2):481-484. |
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| 作者姓名： | 姜文敏 唐罗生 |
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| 作者单位： | 410011,中国湖南省长沙市,中南大学湘雅二医院眼科 |
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| 摘 要： | 系统性微血管病变和糖尿病视网膜病变(diabetic retinopathy,DRP)是糖尿病患者致死性及致盲性的根源,然而其具体机制尚不十分清楚.推测免疫和炎症反应可能涉及其病程及病理进展,尤其对于增殖性视网膜病变(perliferative diabetic retinopathy,PDP),因而有人提出DRP是一种炎症性疾病.本文就炎症反应最具代表性的细胞因子之一--肿瘤坏死因子(tumor necrosis factor,TNF)及其在糖尿病视网膜病变中的可能作用加以综述.
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| 关 键 词： | 糖尿病视网膜病变 肿瘤坏死因子 糖尿病 视网膜病 diabetic retinopathy factor necrosis 作用 tumor 瘤坏死因子 细胞因子 代表 炎症性疾病 增殖性 病理 病程 炎症反应 免疫 机制 致盲 致死性 患者 |
| 文章编号： | 24412102 |
| 修稿时间： | 11 30 2006 12:00AM |
Tumor necrosis factor and diabetic retinopathy |
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| Wen-Min Jiang,Luo-Sheng Tang.Tumor necrosis factor and diabetic retinopathy[J].International Journal of Ophthalmology,2007,7(2):481-484. |
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| Authors: | Wen-Min Jiang Luo-Sheng Tang |
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| Institution: | Department of Ophthamology, the Second Xiangya Hospital of Central-South University, Changsha 410011, Hunan Province, China |
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| Abstract: | Systemic microvascular disease and diabetic retinopathy (DRP) are currently the principal causes of morbidity and mortality in patients with diabetes mellitus,yet the mechanism behind it has not been fully understood. It has been demonstrated that immune phenomena and inflammatory reactions might be involved in the pathogenesis and progression,especially in proliferative DRP. Therefore it has been indicating that DRP is an inflammatory disease. The present paper reviews one of the most representative cell factors,tumor necrosis factor (TNF) and its functions in DRP. |
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| Keywords: | diabetic retinopathy tumor necrosis factor |
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