糖尿病视网膜病变的流行病学、病因学与发病机制研究现状北大核心

糖尿病视网膜病变(DR)是全球工作年龄人群视力丧失的主要原因,根据国际糖尿病地图研究预测,2045年中国糖尿病患者将达1.74亿,DR正在成为全球公共卫生问题。本文就DR的流行病学、病因学、发病机制作一阐述,从DR的流行病学推测疾病将来会波及的人群数量,提醒我们要高度重视本病的预防。从糖尿病的病程发展推测可能的病因学,从氧化应激等反应来研究DR的发病机制,以便开发可靠和有力的手段识别高风险患者,并在视力丧失发生之前进行有效干预。

Research status of epidemiology,etiology and pathogenesis of diabetic retinopathy

Diabetic retinopathy (DR) is the main cause of diabetes-related vision loss in the working-age population worldwide. According to the IDF Diabetes Atlas, it is predicted that there will be 174 million diabetic patients in China by 2045. DR is becoming a global public health challenge. In this paper, the epidemiology, etiology, and pathogenesis of DR are described, and the number of people who will be affected by the disease in the future is estimated from the epidemiology of DR, calling our attention to the prevention of this disease. The possible etiology is explored from the progression of diabetes, and the pathogenesis of DR is investigated from oxidative stress and other reactions, in order that reliable and robust means can be developed to identify high-risk patients and intervene effectively before vision loss occurs.