SARS-CoV-2对眼部的影响及其经眼途径传播的可能性

SARS-CoV-2引起的新型冠状病毒肺炎（COVID-19）已对全球构成重大的公共卫生威胁。SARS-CoV-2和SARS-CoV均属于人冠状病毒（HCoVs）β属，两者的基因组相似性高达79.6%，且均通过血管紧张素转换酶2（ACE-2）感染宿主细胞。目前已有研究表明，SARS-CoV-2感染与结膜炎具有一定相关性，SARS-CoV-2是否能经眼感染或传播的问题也备受关注，但目前尚缺乏其通过眼部组织感染的临床确诊病例和实验室证据。本文就SARS-CoV-2的病原学特点、流行病学特征、眼部表现及结膜囊病毒感染率作一综述，并对SARS-CoV-2经眼途径传播的可能性进行探讨。

Ocular influence and possibility of ocular transmission of SARS-CoV-2

The corona virus disease 2019（COVID-19）pandemic induced by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has become a major global public health threat. Both the SARS-CoV-2 and SARS-CoV etiologic agents belong to the subfamily of beta human coronavirus, and their genomic similarity is up to 79.6%. Both SARS-CoV and SARS-CoV-2 infect the host cell through angiotensin converting enzyme-2. At present, it has been shown that SARS-CoV-2 infection is associated with conjunctivitis. Therefore, that whether the SARS-COV-2 can be infected or transmitted through the eye is also of great concern, but it still a lack of clinically confirmed cases and laboratory evidence of its ocular transmission. This review focuses on the etiological characteristics, epidemiologic features, ocular presentation of SARS-CoV-2 and the conjunctival sac infection rate, and the possibility of SARS-CoV-2 transmission through the ocular tissue will be discussed.