| 程序性细胞死亡的分子机制及其与干性年龄相关性黄斑变性的关系 |
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| 引用本文： | 利虹瑛,李艳,张梦圆,姚勇,蔡季平,谢田华,邵珺.程序性细胞死亡的分子机制及其与干性年龄相关性黄斑变性的关系[J].眼科新进展,2021,0(11):1080-1084. |
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| 作者姓名： | 利虹瑛 李艳 张梦圆 姚勇 蔡季平 谢田华 邵珺 |
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| 作者单位： | 214023 江苏省无锡市，南京医科大学附属无锡人民医院眼科 |
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| 摘 要： | 干性年龄相关性黄斑变性 (AMD) 是一种与年龄高度相关的退行性眼底病变，视网膜色素上皮细胞死亡是AMD致病的主要原因。程序性细胞死亡是一类由特定基因介导并调控的细胞死亡过程，在人体生长发育和疾病发病过程中起着重要的作用。越来越多的研究表明，程序性细胞死亡在AMD的发生发展中起着关键的作用。本文对当前5种常见的程序性细胞死亡的分子机制及其与干性AMD的关系进行综述。
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| 关 键 词： | 年龄相关性黄斑变性 程序性细胞死亡 视网膜色素上皮 |
Molecular mechanism of programmed cell death and its relationship with dry age-related macular degeneration |
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| LI Hongying,LI Yan,ZHANG Mengyuan,YAO Yong,CAI Jiping,XIE Tianhua,SHAO Jun.Molecular mechanism of programmed cell death and its relationship with dry age-related macular degeneration[J].Recent Advances in Ophthalmology,2021,0(11):1080-1084. |
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| Authors: | LI Hongying LI Yan ZHANG Mengyuan YAO Yong CAI Jiping XIE Tianhua SHAO Jun |
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| Institution: | Department of Ophthalmology,Wuxi People’s Hospital Affiliated to Nanjing Medical University,Wuxi 214023,Jiangsu Province,China |
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| Abstract: | Dry age-related macular degeneration (AMD) is a degenerative fundus disease highly related to age. The death of retinal pigment epithelium is the main cause of AMD. Programmed cell death is a kind of cell death mediated and regulated by specific genes. It plays an important role in human growth and development as well as disease occurrence and progression. A great number of studies have shown that programmed cell death plays a key role in the occurrence and development of AMD. This paper reviews the molecular mechanisms of five common programmed cell death and their relationship with dry AMD. |
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| Keywords: | age-related macular degeneration programmed cell death retinal pigment epithelium |
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