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| 杞菊地黄汤对化学诱导光感受器细胞凋亡大鼠的治疗观察 | |
| 引用本文： | 陈金卯,胡世兴,吴开力,杨锦南,林少春,李岱.杞菊地黄汤对化学诱导光感受器细胞凋亡大鼠的治疗观察[J].眼科新进展,2006,26(7):488-490. |
| 作者姓名： | 陈金卯 胡世兴 吴开力 杨锦南 林少春 李岱 |
| 作者单位： | 1. 510060,广东省广州市,中山大学中山眼科中心 2. 100040,北京市,中国中医科学院眼科医院 3. 453003,河南省新乡市,新乡医学院药理教研室 |
| 基金项目： | 国家高技术研究发展计划(863计划) |
| 摘 要： | 目的观察不同剂量杞菊地黄汤对N甲基N亚硝脲(NmethylNnitrosourea,MNU)诱导的大鼠光感受器细胞凋亡的影响。方法SD大鼠分为正常组、模型对照组以及杞菊地黄汤6倍、3倍、1倍和1/3倍各剂量组。TUNEL法检测光感受器细胞的凋亡,常规HE染色测量视网膜外核层的厚度。结果与模型对照组相比,3倍与1倍剂量杞菊地黄汤能显著降低MNU诱导的大鼠外核层细胞凋亡百分率(P<0.01),维持外核层厚度(P<0.01);6倍和1/3倍剂量杞菊地黄汤组大鼠与模型组无差异(P>0.05)。结论3倍与1倍剂量的杞菊地黄汤对MNU诱导的光感受器细胞凋亡有抑制作用。 |
| 关 键 词： | N-甲基-N-亚硝脲 凋亡 杞菊地黄汤 |
| 文章编号： | 1003-5141(2006)07-0488-03 |
| 收稿时间： | 2006-05-01 |
| 修稿时间： | 2006-05-18 |
Evaluation of Qijudihuang decoction for treatment of rats of chemical-induced photoreceptor cells apoptosis |
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| CHEN Jin-Mao,HU Shi-Xing,WU Kai-Li,YANG Jin-Nan,LIN Shao-Chun,LI Dai.Evaluation of Qijudihuang decoction for treatment of rats of chemical-induced photoreceptor cells apoptosis[J].Recent Advances in Ophthalmology,2006,26(7):488-490. | |
| Authors: | CHEN Jin-Mao HU Shi-Xing WU Kai-Li YANG Jin-Nan LIN Shao-Chun LI Dai |
| Institution: | 1,From the Zhongshan ophthalmol Center, Sun Yat-sen University , Guangzhou 510060, Guangdong Province, China ;2, Eye Hospital of China Academy of Traditional Chinese Medicine, Beijing 100040, China; 3,Department of Pharmacology, Xinxiang Medical College , Xinxiang 453003, Henan Province, China |
| Abstract: | Objective To compare the curative effect of several dosages of Qijudihuang decoction for N-methyl-N-nitrosourea (MNU)-induced apoptosis of photoreceptor cells.Methods Sprague Dawley (SD) rats were divided into six groups:the control group,the model group and 6 times,3 times,1 time,1/3 time of the Qijudihuang decoction groups.The photoreceptor cells apoptosis was marked with TUNEL.The thickness of outer nuclear layer was measured by HE coloration.Results Compared with the model control group,the 3 times and 1 time of Qijudihuang decoction could remarkably reduce the apoptotic indexes and sustain the thickness of outer nuclear layer(P<0.01),whereas the 6 times and 1/3 time of Qijudihuang decoction had no significant difference(P>0.05).Conclusion The 3 times and 1 time of Qijudihuang decoction could restrain MNU-induced apoptosis of photoreceptor cells. |
| Keywords: | N-methyl-N-nitrosourea apoptosis Qijudihuang decoction |
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