2型糖尿病住院患者糖尿病视网膜病变患病率及危险因素分析

目的调查40岁以上2型糖尿病(diabetic mellitus,DM)住院患者中糖尿病视网膜病变(diabetic retinopathy,DR)的患病率及危险因素,为DR的临床防治提供依据。方法选取2009年3月至7月广东省人民医院内分泌科住院的40岁以上的2型DM患者240例进行调查,内容包括患者的基本情况、相关病史资料、实验室检查以及眼部检查等,调查DR、增生性糖尿病视网膜病变、糖尿病黄斑水肿的患病率,分析并探讨影响DR发生、发展的危险因素。结果 DR、增生性糖尿病视网膜病变、糖尿病黄斑水肿患病率分别为35.00%、9.17%、7.92%。DM病程、收缩压、胆固醇、肌酐、尿素氮、24h尿白蛋白量、24h尿白蛋白浓度、尿微量蛋白浓度、胰岛素使用、合并周围神经病变、合并肾脏病变与DR的发生、发展有关。Logistic回归分析发现病程、24h尿白蛋白量、合并周围神经病变是DR发生、发展的独立危险因素。结论病程、24h尿白蛋白量、合并周围神经病变是DR发生、发展的独立危险因素。

Prevalence and risk factors of diabetic retinopathy in type 2 diabetic inpatients

Objective To investigate the prevalence and risk factors of diabetic retinopathy(DR) in type 2 diabetic mellitus inpatients over 40 years old,and provide the basis for preventing the DR.Methods From March 2009 to July 2009 in Endocrine Department of Guangdong Province People Hospital,240 inpatients with type 2 diabetic mellitus over 40 years old were studied.All the patients were underwent questionnaires,medical history,physical examinations,laboratory and ophthalmological examinations.The prevalence of DR,proliferative DR and diabetic macular edema were investigated,and the risk factors of DR were analyzed.Results The prevalence of DR,proliferative DR and diabetic macular edema were 35.00%,9.17% and 7.92%.Duration,systolic blood pressure,cholesterol,creatinine,blood urea nitrogen,24 hours urinary albumin volume,24 hours urinary albumin concentration,urine protein concentration,insulin use,whether with peripheral neuropathy,a merger of the occurrence of renal lesions were related with the occurrence and development of DR.Conclusion Duration,24 hours urinary albumin volume and peripheral neuropathy are independent risk factors for occurrence and development of DR.