曲安奈德术中眼内注射对血眼屏障的保护作用

目的评价术中玻璃体腔内注射曲安奈德(triamcinolone acetonide)对复杂的玻璃体视网膜手术术后血眼屏障的保护作用。方法11例(13眼)复杂的玻璃体视网膜手术,手术结束后,将曲安奈德混悬液注入玻璃体腔内,在硅油填充眼,曲安奈德的注入量为0.05mL(2mg),非硅油填充眼为0.1mL(4mg)。手术后随访2~4月,观察曲安奈德颗粒的消失时间、抗炎效果和并发症。结果曲安奈德颗粒从眼内消失的时间,硅油填充眼为2~3月,非硅油填充眼为1~1.5月。术后均未出现明显的早期眼部炎症反应。眼压升高2眼,1眼由硅油引起,另1眼发生在手术后4月,由葡萄膜炎引起。无与曲安奈德相关的并发症发生。结论对复杂的玻璃体视网膜手术,术中玻璃体腔内注射曲安奈德可有效地防止血眼屏障破坏,减轻手术后眼部炎症反应。

Protective effect of triamcinolone acetonide on blood-ocular barrier in complicated vitreoretinal surgery

Objective To evaluate the protective effect of triamcinolone acetonide(TA) on blood-ocular barrier in complicated vitreoretinal surgery by intravitreal injection.Methods After complicated vitreoretinal surgery, 0.05ml(2mg) TA suspension was injected into vitreous body in 9 silicone oil filled eyes and 0.lml(4mg) in 4 non-silicone oil filled eyes.The clearance time of TA,its anti-inflammation effect and complications were observed.The follow-up time was 2-4 months.Results The clearance time of TA in silicone filled eyes was 2-3 months and 1-1.5 months in non-silicone oil filled eyes.No obvious early postoperative inflammation took place in any eye.Intraocular pressure elevated in 2 eyes,1 was induced by silicone oil and another by uveitis. No TA associated complications appeared.Conclusion For complicated vitreoretinal surgery,intravitreal TA injection can effectively protect the breakdown of blood-ocular barrier and decrease postoperative ocular inflammation.