Temporary amniotic membrane patch for the treatment of primary pterygium: mechanisms of reducing the recurrence rate |
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| Authors: | Juan Ye Koung Hoon KooK Ke Yao |
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| Institution: | (1) Department of Ophthalmology, 2nd Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang, People's Republic of China;(2) Department of Ophthalmology, Institute of Vision Research, Yonsei University College of Medicine, Seoul, South Korea;(3) Eye Center, College of Medicine, 2nd Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang, China |
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| Abstract: | Purpose The purpose of the study was to evaluate the outcome of the use of the temporary amniotic membrane patch (TAMP) for the treatment of primary pterygium and to investigate the mechanisms of reducing the recurrence rate.Methods Twenty eyes in 20 patients with primary pterygium underwent pterygium excision followed by TAMP for 5 days. Removed amniotic membrane (AM) was immunostained with primary antibodies CD34, c-Kit, STRO-1 and AC133.Results Within the period of follow-up (53.3±13.8 months), all the eyes showed a smooth ocular surface without recurrence of pterygium. Different grades of CD34, c-Kit, STRO-1and AC133 positive stem and progenitor cells infiltrated or attached to the stroma of patched AM, with more spindle-shaped c-Kit cells than ovoid-shaped CD34 and AC133 cells.Conclusion The temporary amniotic membrane patch is an effective and safe procedure for the treatment of primary pterygium. Absorbing excessive stem and progenitor cells may be one of the mechanisms of reducing the recurrence rate using AM. |
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| Keywords: | Pterygium Progenitor cell Amniotic membrane Recurrence |
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