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Genome-wide Survival Analysis for Macular Neovascularization Development in Central Serous Chorioretinopathy Revealed Shared Genetic Susceptibility with Polypoidal Choroidal Vasculopathy
Institution:1. Department of Ophthalmology, Kyoto University Graduate School of Medicine, Kyoto, Japan;2. Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan;3. Department of Ophthalmology, Osaka Red-Cross Hospital, Osaka, Japan;4. Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Kobe, Japan;5. Department of Bioinformatics and Genomics, Graduate School of Advanced Preventive Medical Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan;6. Department of Ophthalmology and Visual Science, Kochi Medical School, Kochi University, Nankoku City, Kochi, Japan;7. Department of Medical Statistics, Osaka City University Graduate School of Medicine, Osaka, Japan;1. Department of Ophthalmology, The Permanente Medical Group, Kaiser Permanente Northern California, Redwood City, California;2. Department of Ophthalmology, Byers Eye Institute, Stanford University Medical Center, Palo Alto, California;1. Eastern Virginia Medical School, Norfolk, Virginia;2. University of California, Davis School of Medicine, Sacramento, California;3. Department of Ophthalmology and Vision Science, University of California, Davis, Sacramento, California;1. NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust & UCL Institute of Ophthalmology, London, United Kingdom;2. Department of Ophthalmology, University of Calgary, Calgary, Canada;3. MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom;4. UCL Institute of Cardiovascular Science, University College London, London, United Kingdom;5. Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York;6. Brigham and Women’s Hospital / Harvard Medical School, Boston, Massachusetts;7. Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts;8. Clinical Epidemiology and Biostatistics/Nutrient Gut-Brain Interaction, Örebro University, Örebro, Sweden;9. Institute Pasteur, Paris, France;10. BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom;1. Vanderbilt University Medical School, Nashville, Tennessee;2. Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee;3. Department of Ophthalmology and Visual Sciences, Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, Tennessee;1. Department of Ophthalmology, The Second Xiangya Hospital, Changsha, Hunan Province, China;2. College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan, China
Abstract:
Keywords:Central serous chorioretinopathy  Choroidal neovascularization  Genome-wide association study  Macular neovascularization  Survival analysis  AMD"}  {"#name":"keyword"  "$":{"id":"kwrd0040"}  "$$":[{"#name":"text"  "_":"age-related macular degeneration  BCVA"}  {"#name":"keyword"  "$":{"id":"kwrd0050"}  "$$":[{"#name":"text"  "_":"best-corrected visual acuity  CI"}  {"#name":"keyword"  "$":{"id":"kwrd0060"}  "$$":[{"#name":"text"  "_":"confidence interval  CSC"}  {"#name":"keyword"  "$":{"id":"kwrd0070"}  "$$":[{"#name":"text"  "_":"central serous chorioretinopathy  FA"}  {"#name":"keyword"  "$":{"id":"kwrd0080"}  "$$":[{"#name":"text"  "_":"fluorescein angiography  GWAS"}  {"#name":"keyword"  "$":{"id":"kwrd0090"}  "$$":[{"#name":"text"  "_":"genome-wide association study  HR"}  {"#name":"keyword"  "$":{"id":"kwrd0100"}  "$$":[{"#name":"text"  "_":"hazard ratio  ICGA"}  {"#name":"keyword"  "$":{"id":"kwrd0110"}  "$$":[{"#name":"text"  "_":"indocyanine green angiography  IQR"}  {"#name":"keyword"  "$":{"id":"kwrd0120"}  "$$":[{"#name":"text"  "_":"interquartile range  LD"}  {"#name":"keyword"  "$":{"id":"kwrd0180"}  "$$":[{"#name":"text"  "_":"linkage disequilibrium  MAF"}  {"#name":"keyword"  "$":{"id":"kwrd0130"}  "$$":[{"#name":"text"  "_":"minor allele frequency  MNV"}  {"#name":"keyword"  "$":{"id":"kwrd0140"}  "$$":[{"#name":"text"  "_":"macular neovascularization  PCV"}  {"#name":"keyword"  "$":{"id":"kwrd0150"}  "$$":[{"#name":"text"  "_":"polypoidal choroidal vasculopathy  PNV"}  {"#name":"keyword"  "$":{"id":"kwrd0160"}  "$$":[{"#name":"text"  "_":"pachychoroid neovasculopathy  SNP"}  {"#name":"keyword"  "$":{"id":"kwrd0170"}  "$$":[{"#name":"text"  "_":"single nucleotide polymorphism
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