Rosemary as an adjunctive treatment in patients with major depressive disorder: A randomized,double‐blind,placebo‐controlled trial |
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| Institution: | 1. Herbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, Iran;2. Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran;3. Department of Psychiatry, Shahid Beheshti Hospital, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran;4. Department of Clinical Pharmacy, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran;1. Department of Pharmacology, Faculty of Pharmacy, Universidad Complutense de Madrid, Avda. Complutense s/n, 28040 Madrid, Spain;2. Department of Statistics and Operational Research, Faculty of Pharmacy, Universidad Complutense de Madrid, Avda. Complutense s/n, 28040 Madrid, Spain;1. Department of Dermatology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150086, China;2. Department of Dermatology, General Hospital of Northern Theater Command, Shenyang, Liaoning, 110001, China;3. Department of Dermatology, The First Hospital of China Medical University, Shenyang, Liaoning, 110001, China;1. Department of Occupational Therapy, Colorado State University, USA;2. Department of Human Development and Family Studies, Colorado State University, USA;3. Pioneers Medical Center, Meeker, CO;4. Northwest Medical Center Outpatient Therapy, Tucson AZ, USA;1. Department of Midwifery, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran;2. Reproductive Health Promotion Research Centre, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran;3. Department of Psychology, School of Educational Science and Psychology, Shahid Chamran University, Ahvaz, Iran;4. Department of Biostatistics and Epidemiology, School of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran;1. Heart Failure Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran;2. Department of Cardiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran;3. Department of Clinical Pharmacy and Pharmacy Practice, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran;4. Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran;5. Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran;6. Student Research Committee, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran |
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| Abstract: | BackgroundRosemary has shown antidepressant and anxiolytic properties. Thus, the present study aimed at assessing the therapeutic effects of orally administered rosemary capsules in patients with major depressive disorder.Materials and MethodsRosmarinic acid content of rosemary was determined using high performance liquid chromatography method. Hard gelatin capsules of rosemary were prepared, and their physicochemical properties were assessed. In this clinical trial, patients with major depressive disorder were randomly divided into rosemary and control groups. They received one capsule of rosemary or placebo twice a day for 8 weeks. The anxiety subscale of Hospital Anxiety and Depression Scale and Beck Depression Inventory - Second Edition were respectively used to measure the symptoms of anxiety and depression in the patients before initiating the treatment and four and eight weeks after the treatment.ResultsThe amount of rosmarinic acid in rosemary was found to be 21.13 ± 0.56 mg/g dried plant. The scores of anxiety subscale of Hospital Anxiety and Depression Scale and Beck Depression Inventory significantly decreased in the rosemary group compared to those in the control group 8 weeks after the treatment. Memory improvement was a beneficial side effect observed in the study.ConclusionThe use of rosemary as an adjunctive therapy could improve the symptoms of anxiety and depression in people with major depression. |
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| Keywords: | Antidepressant Anxiety Major depressive disorder Rosemary |
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