2007-2008年北京地区25～54岁已婚妇女高危型人乳头状瘤病毒感染的流行病学调查

目的 了解北京地区妇女生殖道高危型人乳头状瘤病毒(HR-HPV)的感染状况及其分布特点,初步探讨HR-HPV感染的相关因素.方法 于2007年3月至2008年9月,采用多阶段整群随机抽样的方法,在北京地区抽取12个区县137个社区25-54岁已婚妇女6185例进行妇科检查、官颈HR-HPV检测及细胞学检查,并进行问卷调查.应用EpiData 3.0软件双次录入、审核数据后,应用SPSS 15.0软件进行统计学分析.结果 (1)北京地区25-54岁已婚妇女生殖道HR-HPV感染率为9.89%.城区、近郊、远郊妇女的HR-HPV感染率分别为9.34%、10.51%和9.51%(P>0.05);本市、外地户籍妇女的HR-HPV感染率分别为9.53%和11.30%(P<0.05).(2)HR-HPV感染的年龄分布特点:25-44岁年龄段妇女的HR-HPV感染率稳定在10%左右,30～34岁者HR-HPV感染牢最高,为11.21%;44岁以上则随着年龄增长感染率逐渐下降,50-54岁降至最低(7.78%).(3)多元logistic回归分析显示,家庭人均月收入≥1000元、配偶性伴侣数>1个者、外地户籍、文化程度为高中及以上者,其感染HR-HPV的町能性大.(4)感染HR-HPV人群的官颈上皮内瘤变(CIN)患病率明显高于未感染人群(分别为29.76%、3.32%,P<0.01).结论 (1)北京地区25～54岁已婚妇女生殖道HR-HPV感染率为9.9%,在地域分布上无差异.(2)北京地区HR-HPV感染的危险人群为家庭经济条件优越者、配偶多个性伴侣者、外地户籍及文化程度较高者.(3)HR-HPV感染是发牛CIN及宫颈癌的重要因素,但HR-HPV感染并不等于一定发生CIN和宫颈癌;应时HRR-HPV感染者定期随访以了解其感染及宫颈的动态变化.

Epidemiological study of high risk human papillomavirus infection in 25 to 54 years old married women in Beijing

Objective To investigate high risk human papillomavirus(HR-HPV)prevalence among married women in Beijing and to study the high risk flactors.nethods During March 2007 to September 2008.a total of 6185 married women sampled from 137 communities in 12 districts were screened bv HR-HPV DNA test and cytogical test.The interview was carried out with unified questionnaires.The databage was set up and twice entered in EpiDam 3.0.After checked up,the data were analyzed in SPSS 15.0.Results (1) The HR-HPV infection rate was 9.89%.The HR-HPV infection rate of the city zone,the suburb and the exurb were 9.34%,10.51% and 9.51% (P>0.05).The HR-HPV infection rate of the native and the oudander were 9.53%,11.30% (P<0.05).(2) The age distribution of HR-HPV infection was that the rate was around 10% among 25 to 44 age groups,which was the highest(11.21%) in 30 to 34 age group;then the rate was descended as the age raising,the rate of 50 to 54 age group was the lowest(7.78%).(3) Multiple logistic regression showed that the related risk factors of HR-HPV infection mainly included 1000 RMB and above of family income per person per month.possessing more than 1 sexual partner of her husband,outlander and hish levels of education.(4) The prevalence of cervical intraepithelial neoplasia(CIN)in HR-HPV positive group wag significantly higher than that in HR-HPV negative group(29.76% vs 3.32%,P<0.01).Conclusions(1)The HR-HPV infection rate among aged 25 to 54 years was 9.9% and there was no significant difference in area distribution.(2)The hish risk population which should strengthen screening was the married bearing-age women with high level of family income,outlander,high levels of education and her husband possessing more than 1 sexual partner.(3)HR-HPV infection is the main risk factor for CIN and cervical cancer.while does not provide a causal relationship with them.The high risk population should be checked regularly to understand the development of HR-HPV infection and CIN incidence.