HE4与妇科肿瘤相关性的研究进展

人附睾蛋白4（HE4）是近年来新兴的肿瘤标记物，许多国内外学者对其进行了相关研究，其最早发现于人附睾上皮远端细胞中，具有抑制蛋白酶的功能，并表达于人体多个组织中。HE4在诊断卵巢癌特别是早期的卵巢癌中具有重要价值，可鉴别诊断卵巢良恶性肿瘤，并在肿瘤复发监测方面具有优越性。同时有研究证明HE4在子宫内膜癌的诊断、分期及预后方面具有指导意义。另外，HE4还可用于子宫内膜异位症、子宫腺肌病等妇科良性疾病的诊断及监测。一直以来我国采用美国推荐的HE4参考值作为诊断标准，缺乏针对我国人群的HE4参考值研究，鉴于此，中国健康人群HE4参考值多中心研究于2012年正式启动，通过对我国人群进行大样本研究，提供HE4参考值范围，这将更好地指导中国医生应用HE4结果进行临床诊疗，有效改善妇科肿瘤的临床管理。

Research Progress of the Correlation between Human Epididymis Protein 4 and Gynecologic Oncology

Human epididymis protein 4 (HE4) is a new tumor biomarker in recent years, many scholars at home and abroad have researched about it. HE4 originally found in people distal epididymal epithelial cells which have the ability to inhibit proteases and express in multiple tissue of the human body. HE4 has important value in diagnosis of ovarian cancer, especially in the early ovarian cancer which can diagnose of benign and malignant ovarian tumors, and also has superiority in monitoring recurrence. At the same time, research has shown that HE4 has a guiding significance in diagnosis, prognosis and staging of endometrial carcinoma. In addition, HE4 can also be used for the diagnosis and monitoring of benign disease of gynecology such as endometriosis, uterine adenomyosis, etc. We has been adopting the recommended HE4 reference value of America as a diagnostic criteria for the lack of crowd HE4 reference research in China. In view of this, HE4 Chinese population reference multicenter study was officially launched in 2012. Through the study of the large sample of people in our country, it provided the reference range of HE4 levels, which will guide Chinese doctor to apply HE4 results for clinical diagnosis and treatment, effectively improve the clinical management of gynecological oncology.