SREBP1、ACLY在卵巢上皮性癌中的表达及临床意义

目的:研究胆固醇调节元件结合蛋白1(SREBP1)、ATP柠檬酸裂解酶(ACLY)在卵巢上皮性肿瘤组织中的表达,探讨其与患者临床病理参数和预后的相关性。方法:采用免疫组织化学法检测SREBP1、ACLY在卵巢良性肿瘤、卵巢交界性肿瘤和卵巢上皮性癌中的表达。结果:SREBP1、ACLY蛋白在卵巢上皮性癌组织中的阳性表达率(67.71%,70.83)显著高于卵巢良性肿瘤(31.25%,37.5%)、卵巢交界性肿瘤(13.33%,13.33%)(P<0.05)。卵巢上皮性癌组织中SREBP1、ACLY蛋白阳性表达率与FIGO分期、组织学分级明显相关(P<0.05);卵巢上皮性癌中SFEBP1蛋白表达与ACLY蛋白的表达呈正相关(r=0.83,P<0.001)。卵巢上皮性癌组织学分级、FIGO分期、SREBP1和ACLY表达水平均与患者预后有关(P<0.05),FIGO分期是影响卵巢癌患者预后的独立因素(P<0.05)。结论:SREBP1、ACLY蛋白与卵巢上皮性癌的发生、发展和预后有关。SREBP1、ACLY可能成为治疗卵巢癌的新靶点。

Expression of SREBP1 and ACLY proteins in epithelial ovarian carcinoma and its clinical significance

Objective： To explore the sterol regulatory element-binding proteinl （SREBP1） and ATP cirate tyase （ACLY） expression in ovarian carcinoma tissues, and to investigate their correlation with the clinical and pathological features and the prognosis of the patients. Methods：The expression of SREBP1 and ACLY were detected by Immunohistochemistry （IHC） in benign ovarian tumor, borderline ovarian tumor and ovarian carcinoma. Results：The Positive rate of expression of SREBP1 and ACLY in ovarian carcinoma tissue （67.71% , 70.83 ）were significantly higher than those in ovarian benign tumors （31.25% , 37.5% ） and ovarian borderline tumors （ 13.33%, 13.33% ） （P〈0.05）. The expression levels of SREBP1 and ACLY had significant correlation with the FIGO surgical stage and histological grade in ovarian carcinoma （P〈0.05）. Furthermore, the expression of SREBP1 had positive correlation with ACLY expression （r = 0.83 ,P〈0. 001 ）. FIGO surgical stage, histological grade and the ex- pression of SREBP1 and ACLY were all related to the prognosis （P〈0.05）. However, only the FIGO surgical stage retained significance in prospecting prognosis. Conclusion：The expressions of SREBPI and ACLY may promote development and prognosis of ovarian carcinoma. They may become a new treatment targets for ovarian cancer.