宫腔粘连分离术后行鲜胚移植活产的影响因素分析

目的探究宫腔粘连分离术(TCRA)后患者接受IVF治疗的活产率及其影响因素。方法选择2014年1月至2019年12月于山东大学附属生殖医院行TCRA手术治疗后接受IVF助孕的635例宫腔粘连(IUA)患者。随访其妊娠结局,并分析可能影响活产率的因素。结果TCRA术后患者行鲜胚移植的活产率为36.7%。年龄(OR=0.930,P<0.001)、AFS评分(OR=0.898,P=0.035)、移植胚胎数(OR=1.875,P=0.001)、促性腺激素(Gn)启动量(OR=0.994,P=0.001)是活产率的独立影响因素。结论年龄、AFS评分、移植胚胎数、Gn启动量可能是活产率的独立影响因素。对于TCRA术后准备接受IVF鲜胚移植的患者,医生应根据以上因素制定个体化治疗方案。

Influencing factors of live birth rate in IUA patients with IVF treatment after TCRA

Objective:To investigate the pregnancy rate and its influencing factors after transcervical resection of uterine adhesions(TCRA)in patients with IVF treatment.Methods:635 patients with intrauterine adhesions received IVF assistance after TCRA surgery in the Affiliated Reproduction Hospital of Shandong University from January 2014 to December 2019 were selected.Then followed up pregnancy outcomes and analyzed factors that might influence the live birth rate.Results:The live birth rate of fresh embryo transplantation after TCRA was 36.7%.Age(OR=0.930,P<0.001),AFS score(OR=0.898,P=0.035),number of embryos transferred(OR=1.875,P=0.001)and gonadotropins(GN)starting dose(OR=0.994,P=0.001)were independent determinants of live birth rate.Conclusion:Age,AFS score,the number of embryos transferred and the number of GN starting dose may be independent factors affecting the live birth rate.Doctors should make individualized treatment plans for patients preparing for fresh IVF embryo transplantation after TCRA based on the above factors.